抗痨合剂对耐多药肺结核患者外周血VEGF水平的影响

Effects of Kanglao Mixture(抗痨合剂) on Serum VEGF Level in MDR-FTB Patients

目的:观察抗痨合剂对耐多药肺结核患者外周血VEGF表达的影响。方法:50例耐多药肺结核患者随机分为2组,观察组(26例)应用抗痨合剂+二线化疗药物,对照组(24例)予安慰剂加二线化疗药物;观察临床疗效并采用ELISA法检测2组强化期化疗前后VEGF的含量。结果:经强化期治疗后,观察组患者外周血VEGF的含量低于对照组,两者差异有统计学意义(P<0.05);观察组患者血清中VEGF的水平在强化期治疗前后差异有统计学意义(P<0.05)。结论:抗痨合剂可能是通过下调耐多药肺结核患者外周血VEGF的表达,抑制耐多药肺结核患者血管形成,从而发挥治疗作用。

Objective ：To observe the effect of Kanglao Mixture on the expression of VEGF in multi - drug resistant pulmonary tuberculosis （ MDR - PTB） patients Methods： 55 cases of MDR - FTB were randomly divided into two groups. Chinese medicine group （26 cases） was treated with both Kanglao Mixture and anti - tu- berculosis drugs, control group （24 cases） was treated with both placebo and anti -tuberculosis drugs. The treatment course was 6 months. The curative effect was observed. VEGF level was determined with ELISA. Results： Kanglao Mixture could relieve clinical symptom of MDR - FTB patients. The level of VEGF in peripheral blood was lowered in Kanglao Mixture group that was lower than that in control group （P 〈 0. 05 ）. The level of VEGF in peripheral blood was also lowered in Kanglao Mixture group to compare with before treatment （P 〈 0. 05 ） Conclusion： Kanglao Mixture could play a role in anti - tuberculosis therapy by reducing the level of VEGF.