2型糖尿病大鼠在有氧运动干预中Apelin的变化及其对血压的调节作用

Changes of Apelin in Type 2 Diabetic Rats During Aerobic Exercise Intervention and Its Regulation on Blood Pressure

目的探讨2型糖尿病(T2DM)在膳食控制和有氧运动干预过程中的Apelin变化及其对血压的调节作用。方法对T2DM大鼠进行为期12周的有氧运动干预,在测定大鼠血压的同时,测定空腹血清apelin、一氧化氮(NO)和血浆血栓素B_2(TXB_2)、6-酮-前列腺素F1α(6-keto-PGF1α)含量。结果 (1)与正常大鼠相比,T2DM大鼠收缩压(SBP)、舒张压(DBP)和血浆TXB_2含量显著升高,而血清apelin、NO含量显著降低;(2)长期的有氧运动可使T2DM大鼠SBP、DBP和血浆TXB_2含量显著降低,血清Apelin和NO含量显著增加(P<0.05)。结论 (1)随着T2DM的发展,apelin、NO生成减少,TXA_2生成增多,从而导致血压的显著升高。(2)长期有氧运动可抑制TXA_2生成,促进apelin和NO生成,对防止T2DM大鼠血压的升高具有非常重要的作用。

Objective To explore the changes of Apelin in type 2 diabetes mellitus（T2DM） during the intervention of the diet control and aerobic exercise and its regulation on blood pressure. Methods T2 DM rats were conducted aerobic exercise and/or diet control for 12 weeks,blood pressure,fasting serum apelin,nitric oxide（NO） and plasma TXB_2、6-keto-PGF1αcontent were measured. Results（1） Compared with normal rats,systolic blood pressure（SBP）,diastolic blood pressure（DBP） and plasma TXB_2 level in T2 DM rats were significantly increased,while the content of serum Apelin,NO were significantly reduced.（2） Long-term aerobic exercise could significantly decrease the SBP,DBP and plasma TXB_2 content,and increase serum Apelin and NO content in T2 DM rats（P〈 0. 05）. Conclusions（1） With the development of T2 DM,the decrease of apelin and NO production and the increase of TXA_2 production,resulting in a significant increase of blood pressure.（2） Long-term aerobic exercise could restrain the production of TXA_2 and promote the production of apelin and NO,which had a very important role to prevent the increase of blood pressure in T2 DM rats.