高同型半胱胺酸血症与帕金森病认知功能的相关性研究

Association between hyperhomocysteinemia and cognitive impairment in Parkinson's disease

目的探究高同型半胱胺酸血症与帕金森病认知功能相关性。方法选取我院收治的130例帕金森病患者作为试验组,同期的健康体检人员110例作为对照组,对影响认知功能的可能危险因素进行Logistic回归分析,并将轻度认知功能障碍患者、痴呆患者及健康人群血清高同型半胱胺酸含量进行对比。结果经Logisitc非条件回归分析可见,年龄、文化程度、吸烟、高血压、糖尿病、高密度脂蛋白、低密度脂蛋白、血清总胆固醇、血浆同型半胱氨酸为认知功能障碍的危险因素。对照组与帕金森非认知障碍组、帕金森认知障碍组的血浆同型半胱氨酸含量相比差异均具有统计学意义(t=3.45,P<0.05;t=6.43,P<0.05)。帕金森非认知功能障碍组与帕金森认知功能障碍组的血浆同型半胱氨酸含量相比差异具有统计学意义(t=5.23,P<0.05)。结论帕金森病认知功能障碍患者同型半胱胺酸含量明显高于无认知功能障碍的帕金森病患者及健康人群,高同型半胱胺酸血症为帕金森病认知功能障碍的危险因素,可作为临床医师可靠的诊断依据。

Objective To investigate the association between hyperhomocysteinemia and cognitive impairment in Parkinson＇s disease.Methods A total of 130 patients with Parkinson＇s disease who were admitted to our hospital were selected as the experimental group,and 110 healthy persons who underwent physical examination during the same period were enrolled as the control group. A logistic regression analysis was performed to identify the possible risk factors for cognitive impairment,and the serum level of homocysteine was compared between the patients with mild cognitive impairment,the patients with dementia,and healthy controls. Results The unconditional logistic regression analysis showed that age,educational level,smoking,hypertension,diabetes,high-density lipoprotein,lowdensity lipoprotein,serum total cholesterol,and plasma homocysteine were risk factors for cognitive impairment. Compared with the Parkinson＇s disease patients with or without cognitive impairment,the control group had a significantly different level of plasma homocysteine（ t =3. 45,P〈0. 05; t = 6. 43,P〈0. 05）. The level of plasma homocysteine showed a significant difference between the Parkinson＇s disease patients with and without cognitive impairment（ t = 5. 23,P〈0. 05）. Conclusions The Parkinson＇s disease patients with cognitive impairment have a higher level of homocysteine than those without cognitive impairment and healthy persons. Hyperhomocysteinemia is the risk factor for cognitive impairment in Parkinson＇s disease and can be used as a reliable indicator for diagnosis.