Chemoselective synthesis of novel aminoindolizines using aminopyridines, acetylenic diesters and α-halo ketones
Chemoselective synthesis of novel aminoindolizines using aminopyridines, acetylenic diesters and α-halo ketones
摘要
A chemoselective synthesis of novel indolizine derivatives were reported via three-component reactions of aminopyridines, acetylenic diesters and a-halo ketones. In these reactions, the zwitterion generated from aminopyridines and acetylenic diesters reacted with a-halo ketones to produce indolizine skeleton in good to high yields under mild reaction conditions.
A chemoselective synthesis of novel indolizine derivatives were reported via three-component reactions of aminopyridines, acetylenic diesters and a-halo ketones. In these reactions, the zwitterion generated from aminopyridines and acetylenic diesters reacted with a-halo ketones to produce indolizine skeleton in good to high yields under mild reaction conditions.
基金
supported by the Research Council of the University of Mazandaran,Iran
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