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A facile synthesis of 6-amino-2H, 4H-pyrano[2,3-F]pyrazole-5-carbonitriles in deep eutectic solvent 被引量：1

A facile synthesis of 6-amino-2H, 4H-pyrano[2,3-F]pyrazole-5-carbonitriles in deep eutectic solvent
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摘要 A convenient synthesis of 6-amino-2H,4H-pyrano[2,3-F]pyrazole-5-carbonitriles has been accomplished by one pot four-component cyclocondensation of aromatic aldehydes（1a-o） malanonitrile（2）, ethyl acetoacetate（3）, and hydrazine hydrate（4） in freshly prepared deep eutectic solvent, DES（choline chloride：urea）. This protocol has afforded corresponding pyrano[2,3-F]pyrazoles in shorter reaction time with high yields, and it avoids the use of typical toxic catalysts and solvents. A convenient synthesis of 6-amino-2H,4H-pyrano[2,3-F]pyrazole-5-carbonitriles has been accomplished by one pot four-component cyclocondensation of aromatic aldehydes（1a-o） malanonitrile（2）, ethyl acetoacetate（3）, and hydrazine hydrate（4） in freshly prepared deep eutectic solvent, DES（choline chloride：urea）. This protocol has afforded corresponding pyrano[2,3-F]pyrazoles in shorter reaction time with high yields, and it avoids the use of typical toxic catalysts and solvents.
作者 Manisha R.Bhosle Lalit D.Khillare Sambhaji T.Dhumal Ramrao A.Mane
机构地区 Department of Chemistry
出处 《Chinese Chemical Letters》 SCIE CAS CSCD 2016年第3期370-374,共5页 中国化学快报（英文版）
关键词 Choline chloride Cyclocondensation DES One pot Urea Pyranopyrazoles Choline chloride Cyclocondensation DES One pot Urea Pyranopyrazoles
分类号 O626 [理学—有机化学]
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Chinese Chemical Letters
2016年 第3期

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