期刊文献+

血液系统常见病T淋巴细胞亚群检测及临床价值的分析 被引量:3

下载PDF
导出
摘要 目的检测11种常见血液病患者T淋巴细胞亚群并分析其临床价值。方法采用流式细胞仪(FCM)检测常见血液病,包括红细胞系统疾病、白细胞系统疾病、出血性疾病外周血T淋巴细胞亚群(CD3+CD4+/CD3+、CD3+CD8+/CD3+、CD3+CD4+/CD3+CD8+)的变化关系。结果再生障碍性贫血(AA)、急性白血病(AL)、骨髓增生异常综合症(MDS)、非霍奇金淋巴瘤(NHL)、免疫性血小板减少性紫癜(ITP)、自身免疫性溶血性贫血(AIHA)患者外周血CD4+、CD4+/CD8+、CD8+百分比与对照组比较差异具有统计学意义,P<0.05。结论血液系统疾病多存在T淋巴细胞亚群的功能变化,通过该项检测有助于常见血液病的诊断和鉴别诊断,了解发病机制、指导治疗,特别对再障、血液系统肿瘤、免疫相关的血液疾病更有临床价值。
作者 刘聪 葛繁梅
出处 《延安大学学报(医学科学版)》 2016年第1期29-31,共3页 Journal of Yan'an University:Medical Science Edition
  • 相关文献

参考文献9

  • 1张之南,郝玉书,赵永强,等.血液病学[M].第2版,人民卫生出版社.2003 : 1273 - 1277.
  • 2Young NS,Calado RT,Scheinberg P. Current concepts in thepathophysiology and treatment of aplastic anemia[ J]. Blood,2006,108(8):2509-2519.
  • 3Barker RN,Elson CJ. Red blood cell glycoPhorins as B andT - cell antigens in canine autoimmune hemolytic anaemia[J]. Vet Immunol ImmunoPathol, 1995,47 (3 - 4) :225 -238.
  • 4陈彦明,伍昌林,戴凤燕.自身免疫性溶血性贫血患者外周血T细胞亚群的检测[J].临床输血与检验,2005,7(4):244-247. 被引量:6
  • 5LiX,Xu F,He Q,et al. Comparison of Immunological Ab-normalities of LymPhocytes in Bone Marrow in Myelodys-Plastic Syndrome ( MDS) and Aplastic Anemia( AA) [ J].Internal Medicine,2010, 49(14) :1349-1355.
  • 6Serio B, Risitano AM, Giudice V. Immunological derange-ment in HyPocellular MyelodysPlastic Syndromes [ J ].Translational Medicine,2014,8(5) ; 31 -42.
  • 7Xiao - Lin Zhang, Jun Peng, Jian - Zhi Sun, et al. De novoinduction of Platelet - sPecific CD4 (+) CD25 (+) regula-tory T cells from CD4( + ) CD25( - ) cells in Patients withidioPathic thrombocytoPenic PurPura[ J] . Blood, 2009,12(113):2568-2577.
  • 8葛繁梅,张筱东,张雯,任羽,刘卉,刘宇宏,曹慧琴,苏保雄.难治性血小板减少性紫癜靶向干预治疗及免疫功能分析[J].血栓与止血学,2013,19(6):254-256. 被引量:6
  • 9李秋,杨锡强,李永柏,王莉佳.过敏性紫癜T淋巴细胞功能状态的研究[J].中华儿科杂志,2001,39(3):157-159. 被引量:105

二级参考文献18

  • 1张晓丽,刘延方,孙慧,谢新生,姜中兴,孙玲,万鼎铭,刘林湘.重组人血小板生成素治疗难治性特发性血小板减少性紫癜临床观察[J].中国实用医刊,2010,37(7):17-18. 被引量:3
  • 2Cosmi L ,Annunziato F ,Galli MIG,et al. CRTH2 is the most reliable marker for the detection of circulating human type 2 Th and type 2 T cytotoxic cells in healthand disease [J]. Eur J Immunol, 2000, 30 (10) : 2972-2979.
  • 3Woodland DL,Dutton RW. Heterogeneity of CD4(+ )and CD8 (+) T cells[J]. Curr Opin Immunol, 2003,15(3) : 336-342.
  • 4Mosmann TR ,Sad S. The expanding universe of T-cell subsets : Thl,Th2 and more[J]. Immunol Today, 1996,17(3) :138-146.
  • 5Tsuda H,Michimata T ,Sakai M ,et al. A novel surface molecule of Th2- and Tc2-type cells,CRTH2 expression on human peripheral and decidual CD4^+ and CD8^+ T cells during the early stage of pregnancy[J]. Clin Exp Immuno1,2001,23(1) : 105-111.
  • 6Nagata K ,Tanaka K ,Ogawa K ,et al. Selective expression of a novel surface molecule by human Th2 cells in vivo[J]. J Immunol,1999,162(3):1278-1286.
  • 7Fagiolo E,Toriani-Terenzi C. Th1 and Th2 eytokine modulation by IL-10/IL-12 imbalance in autoimmune haemolytie anaemia (AIHA) [J]. Autoimmunity, 2002,35(1) :39-44.
  • 8Toriani-Terezi C,Fagiolo E. Th2 eytokine role in autoimmune haemolytie anaemia(AIHA) pathogenesis [J].Panminerva Med ,2001,4S(1 ) : 1-5.
  • 9Youssef AR ,Shen CR ,Lin CL,et al. IL-4 and IL-10 modulate autoimmune haemolytic anaemia in NZB mice[J]. Clin Exp Immunol,2005,139(1) : 84-89.
  • 10XU L,ZHAO H, LU A, et al. Down- regulation of Treg cells and up- regulation of THI/TH2 cytokine ratio were induced by polysaccharide from Radix Giycyrrhizae in H22 hepatocarcinoma bearing mice. [ J]. Molecules,2011 30 ;16(10) :8343-8352.

共引文献114

同被引文献23

引证文献3

二级引证文献25

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部