老年慢性阻塞性肺病患者血清TGF-β1、IL-13、TNF-ɑ水平变化及其与肺功能相关性研究被引量：2

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摘要目的探讨老年慢性阻塞性肺疾病(COPD)患者血清TGF-β1、IL-13、TNF-ɑ水平与肺功能的关系。方法选取延安大学附属医院45例COPD急性加重期(A组)老年患者和经治疗后其症状明显缓解处于COPD稳定期(B组)的40例老年患者为研究对象。另选择同期体检的健康查体者45例为对照组。应用ELISA法测定各组血清TGF-β1、IL-13、TNF-ɑ的浓度,并对进行肺功能检查。结果 A组患者血清TGF-β1、IL-13、TNF-ɑ浓度显著高于B组和对照组(P<0.01),B组患者血清TGF-β1、IL-13、TNF-ɑ浓度显著高于对照组(P<0.01);A组患者肺功能指标VC、FEV1、FEV1/FVC、PEF均显著低于B组和对照组(P<0.01),稳定期组患者VC、FEV1、FEV1/FVC、PEF均显著低于对照组(P<0.01)。A组及B组患者血清TGF-β1浓度与肺功能指标中的VC、FEV1、FEV1/FVC、PEF均呈负相关(P<0.05或P<0.01)。结论血清TGF-β1、IL-13、TNF-ɑ浓度可作为判断COPD急性加重期患者炎症反应程度的辅助诊断指标,且血清TGF-β1浓度变化与患者肺功能下降密切相关。

作者折乐乐刘亚东谷秀娟

机构地区延安大学医学院延安大学附属医院检验科

出处《延安大学学报（医学科学版）》 2016年第1期35-37,共3页 Journal of Yan'an University:Medical Science Edition

关键词慢性阻塞性肺病转化生长因子-β1 白细胞介素-13 肿瘤坏死因子-A 肺功能

分类号 R563.9 [医药卫生—呼吸系统]

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