加味四君子汤对慢性阻塞性肺病患者肺功能和生活质量的影响

The effect of modified Sijunzi decoction on pulmonary function and quality of life of patients with chronic obstructive pulmonary disease

目的探讨加味四君子汤对慢性阻塞性肺疾病（COPD）患者肺功能和生活质量的影响。方法选择2012-12~2014-01甘肃省人民医院西区分院收治的中重度COPD患者65例,随机分为对照组和观察组,对照组采用西医治疗,观察组在西医治疗基础上联用加味四君子汤,分别在治疗前后采用肺功能仪测定肺活量（FVC）、1 s用力呼气容积（FEV1）和FEV1/FVC%,应用CAT表、6 min步行距离（6MWT）和圣乔治呼吸问卷（SGRQ）评估患者临床症状、运动耐力和生活质量。结果与治疗前比较,两组患者治疗后FVC、FEV1、FEV1/FVC%以及6MWT明显升高,而CAT评分、呼吸症状、活动受限、疾病影响评分以及SGRQ总分显著降低（P〈0.05）;与对照组治疗后比较,观察组治疗后FVC、FEV1、FEV1/FVC%以及6MWT较高而CAT评分、呼吸症状、活动受限和SGRQ总分较低（P〈0.05）。结论加味四君子汤对改善中重度COPD患者肺功能和生活质量具有较好的疗效。

Objective To explore the effect of modified Sijunzi decoction on pulmonary function and quality of life of patients with chronic obstructive pulmonary disease（ COPD）. Methods 65 cases with moderate to severe COPD were chosen and divided into control group and observation group according to the random number table in our hospital from December 2012 to January 2014. The control group was given western medicine while the observation group was given modified Sijunzi decoction on basis of western medicine. The vital capacity（ FVC）,forced expiratory volume in one second（ FEV1） and FEV1/ FVC% were detected by lung function instrument before and after the treatment respectively. The clinical symptoms,exercise tolerance and quality of life were evaluated using CAT table,six minutes walking distance（ 6MWT） and the St. George＇s Respiratory Questionnaire（ SGRQ）. Results Compared with pro- treatment,the FVC,FEV1,FEV1/ FVC% and 6MWT increased significantly while CAT score,respiratory symptoms,activity limitation,disease influence score and total score of SGRQ significantly decreased（ P 0. 05） in the two groups after treatment; compared with the control group after treatment,FVC,FEV1,FEV1/FVC% and 6MWT was higher while CAT score,respiratory symptoms,limitation of activity and SGRQ score were lower（ P 〈0. 05）. Conclusion Modified Sijunzi decoction can improve the pulmonary function and quality of life of patients with moderate to severe COPD.