132例抗肿瘤药物不良反应分析

Analysis of 132 Cases Adverse Drug Reactions of Antineoplastic Drugs

目的分析本院肿瘤科抗肿瘤药致不良反应发生的特点及一般规律,以减少临床肿瘤药物不良反应的发生。方法对本院肿瘤科2014年涉及的132例抗肿瘤药致ADR进行统计和分析。结果 ADR多发生于40岁以上的男性(61.36%);发生不良反应最多的给药途径为静脉滴注(62.81%);ADR累及的系统主要为消化系统(40.20%)和血液系统(32.17%),其中发生率最高的化疗方案均为"紫杉醇+顺铂"。结论肿瘤科临床药师应积极主动监测抗肿瘤药的ADR,以促进临床合理用药,预防和减少ADR的发生。

OBJECTIVE To investigate the characteristics and regularity of adverse drug reactions of antineoplastic drugs in the Tumor department in order to reduce the occurrence of ADR. METHODS Antineoplastic agents-induced ADR in the Tumor department in 2014 were analyzed statistically. RESULTS ADR of antineoplastic drugs mainly occurred in male patients aged 40 years above（ 61.36%）. Intravenous dripping was the main route of administration（ 62.81%）. The organs or systems involved in ADR was digestive system（ 40.20%） and blood system（ 32.17%）,chemotherapy regimens of the high rates of which both is paclitaxel plus cis-platinum. CONCLUSION Clinical pharmacist in Tumor department should take initiative to monitor ADR of antineoplastics drugs,in order to promote clinical rational application of drugs,prevent and reduce the occurrence of ADR.