补肾破血通络方治疗早期糖尿病肾病疗效观察

Clinical Observation of Bushen Poxue Tongluo Formula in Treating Early Diabetic Nephropathy

目的 :观察补肾破血通络方治疗早期糖尿病肾病的临床疗效。方法 :依照Mogensen诊断分期标准,选择早期糖尿病肾病患者80例为研究对象。患者采用随机数字表法分为治疗组和对照组各40例,治疗组采用糖尿病基础治疗,加用补肾破血通络方,对照组采用糖尿病基础治疗,加缬沙坦80 mg口服,治疗8周后观察两组治疗前后中医证候积分,24 h尿蛋白定量及综合疗效变化,并进行两组疗效比较。结果:补肾破血通络方可明显改善证候积分,减少尿中微量蛋白,显著改善综合疗效,总有效率治疗组97.5%,对照组62.5%,两组疗效比较差异有统计学意义(P<0.05)。结论:补肾破血通络方能有效治疗早期糖尿病肾病,在减少尿中微量蛋白及减缓肾功能损害方面有一定优势。

Objective：To investigate the curative effect of Bushen Poxue Tongluo formula on early diabetic nephropathy（DN）. Methods：DN patients（n=80） were chosen according to Mogensen criterion and divided randomly into treatment group and control group（n=40）. The control group was treated with Valsartan besides of basic treatment. Treatment group was treated with Bushen Poxue Tongluo formula besides of the same treatment as the control group. After 8 weeks,observed the curative effect of syndrome integrals,quantitation of urine protein,combining effect and analyzed statistically. Results：Bushen Poxue Tongluo formula decrease syndrome integrals,reduce quantitation of urine protein,improve combining effect. The total effective rate in the treatment group was higher than that in the control group（P〈0.05）,with 97.5% in the treatment group and 62.5% in the control group. Conclusion：Bushen Poxue Tongluo formula can effectively treat early DN,reduce quantitation of urine protein,improve kidney function.