养肺方治疗老年晚期非小细胞肺癌氩氦刀冷冻术后并发症的临床研究

Clinical Observation on Yangfei Fomula's Effect on Reducing Postoperative Complications of Elderly Patients with Advanced Non-Small Cell Lung Cancer after Argon-Helium Cryoablation

目的:探讨养肺方减轻老年晚期非小细胞肺癌(NSCLC)患者接受氩氦刀冷冻术后并发症的临床疗效。方法:将86例接受氩氦刀冷冻治疗患者按照意愿分为中西医结合组45例(养肺方+最佳对症治疗)和西医治疗组41例(仅予最佳对症支持),评价其术后并发症的发生次数和缓解时间、体力状况和临床症状。结果:1)术后并发症:2组病例氩氦刀术后并发症均以咳嗽加重最多见,其次为术后疼痛,第三为咯血/痰中带血,经常规对症治疗后,中西医结合组咳嗽缓解时间(5.11±2.17)d,比西医治疗组(6.68±3.12)d短(P<0.05);中西医结合组术后疼痛缓解时间(3.47±1.92)d,比西医治疗组(5.35±2.06)d短(P<0.05);2)术后PS评分:术后1个月和术后3个月中西医结合组PS评分改善情况均优于西医治疗组,差异具有统计学意义(P<0.05);3)临床症状:术后1个月中西医结合组中咯痰、神疲乏力及食欲不振症状改善情况优于西医治疗组(P<0.05);术后3月中西医结合组咳嗽、咯痰量、胸痛、神疲乏力、口干咽燥及食欲不振等症状改善情况优于西医治疗组(P<0.05)。结论:老年晚期NSCLC患者氩氦刀冷冻术后服用养肺方,可缩短术后并发症缓解时间、改善体力状况和临床症状。

Objective： To observe the clinical effect of Yangfei fomula’s effect on reducing postoperative complications for elderly patients with advanced non-small cell lung cancer（ NSCLC） after Argon-Helium cryoablation. Methods： A total of 86 elderly advanced NSCLC patients were included in this study. Patients were divided into 2 groups. The group of combination of traditional Chinese and western medicine（ group I） including 45 patients was given the treatment of Yangfei fomula combined with best supportive care（ BSC） after argon-helium cryoablation. The group of western medicine multi-modality（ group II） including 41 patients was given the treatment of BSC. Postoperative complications,PS score and clinical symptoms were observed. Results： 1）Postoperative complications： The most common complications were aggravating cough,pain of surgical site,hemoptysis and blood in phlegm. The relief time of cough in group I（ 5. 11 ± 2. 17 d） was shorter than group II（ 6. 68 ± 3. 12d） with statistical difference（ P 〈 0. 05）. The relief time of pain in group I（ 3. 47 ± 1. 92d） was shorter than group II（ 5. 35 ± 2. 06d） with statistical difference（ P 〈 0. 05）. 2） PS score： The PS score of group I was superior to group II 1 month and 3 month after surgery respectively（ P 〈 0. 05）. There was no statistical difference 1 week after surgery（ P 〉 0. 05）. 3） Clinical symptoms： The improvement of expectoration,god fatigue,and loss of appetite in group I was superior to group II 1 month after surgery（ P 〈 0. 05）. The improvement of cough,expectoration,god fatigue,dry throat,and loss of appetite in group I was superior to group II 3 month after surgery（ P 〈 0. 05）. Conclusion： Yangfei fomula could reduce postoperative complications and improve physical condition of elderly patients with advanced non-small cell lung cancer（ NSCLC） after Argon-Helium cryoablation.