干黄茶乳剂对慢性牙周炎患者龈沟液中TNF-α、IL-6和IL-10水平的影响及疗效观察

The Influence of Ganhuangcha Cream on TNF-α,IL-6 and IL-10 Levels in Gingival Crevicular Fluid of Patients with Chronic Periodontitis and its Curative Effect

目的:观察干黄茶乳剂对慢性牙周炎患者龈沟液中TNF-α、IL-6和IL-10水平的影响及其疗效。方法:慢性牙周炎患者82例随机分为治疗组(41例)和对照组(41例)。2组患者均给予龈上洁治、龈下刮治和根面平整等常规牙周基础治疗。治疗组给予干黄茶乳剂注满牙周袋内,对照组给予等量复方碘甘油液。1次/周,连续6周治疗。观察2组患者治疗前后龈沟液中TNF-α、IL-6和IL-10水平变化,比较临床有效率。结果:治疗结束后,2组患者龈沟液中TNF-α、IL-6水平均明显下降,IL-10水平明显升高(P<0.05或P<0.01),且治疗组下降或升高幅度较对照组更显著(P<0.05)。治疗组临床总有效率为95.12%,明显优于对照组75.61%(P<0.05)。结论:干黄茶乳剂局部治疗慢性牙周炎的效果良好,能够降低龈沟液中TNF-α、IL-6水平,提高IL-10水平,从而有效控制牙周组织炎性反应损伤,改善局部炎性反应状况。

Objective： To observe the influence of Ganhuangcha cream and its influence on tumor necrosis factor-α（ TNF-α）,interleukin-6（ IL-6） and interleukin-10（ IL-10） levels in gingival crevicular fluid of patients with chronic periodontitis. Methods： A total of 82 cases of patients with chronic periodontitis were selected and divided into observation group（ 41 cases） and control group（ 41 cases） by random number table. All patients were given the routine periodontal non-surgical treatment,including supragingival scaling,subgingival scaling,scaling and root planning. The patients in the observation group were given Ganhuangcha cream filled in the periodontal pockets,and the control group were given compound iodine glycerol liquids,the treatment was performed once a week,lasting for 6 weeks. The changes in TNF-α,IL-6 and IL-10 levels in gingival crevicular fluid of patients before and after treatment were observed,and the curative effect was compared as well. Results： After treatment,the levels of TNF-α and IL-6 in the two groups were obviously declined,and the IL-10 levels were obviously increased（ P 〈 0. 05 or P 〈 0. 01）. Besides,the change degree of the observation group was much higher than that of the control group（ P 〈 0. 05）. The total clinical efficiency in the observation group（ 95. 12%） was much higher than that of the control group（ 75. 61%）（ P 〈 0. 05）. Conclusion：Ganhuangcha cream has favorable clinical effect in treating chronic periodontitis. It can reduce TNF-α and IL-6 levels in gingival crevicular fluid and increase IL-10 levels; thus controlling the inflammatory damage in periodontium effectively and improving the local inflammation..