桑椹首乌补脑颗粒对老年性痴呆模型大鼠血清SOD、MDA含量及脑组织β淀粉样蛋白表达的影响

Effects of Sangshen Shouwu Bunao Granule on the Level of SOD,MDA and the Expression ofβ-amyloid in Dementia Model Rats Serum

目的:研究桑椹首乌补脑颗粒防治老年性痴呆的作用机制,为指导临床用药提供实验依据。方法:观察服用桑椹首乌补脑颗粒后,老年性痴呆模型Wistar大鼠学习记忆功能、血管活性物质(SOD、MDA)及脑组织β淀粉样蛋白含量的变化。结果:桑椹首乌补脑颗粒能够促进学习记忆功能的恢复,升高SOD、降低MDA含量,降低海马区β淀粉样蛋白的表达。结论:桑椹首乌补脑颗粒防治老年性痴呆可能是通过下调脑组织β淀粉样蛋白的表达,升高SOD水平、降低MDA含量,减少脑组织损伤有关。

Objective： To explore the mechanism of Sangshen Shouwu Bunao granule on preventing dementia and provide data support on clinical treatment. Methods： To detect the changes of SOD,MDA and β-amyloid on Alzheimer Wistar rats after giving Sangshen Shouwu Bunao granule. Results： Sangshen Shouwu Bunao granule can promote the learning and memory capabilities of rats,increase SOD,decrease MDA level and down regulate amyloid β expression. Conclusion： Sangshen Shouwu Bunao granule can prevent Alzheimer’s disease. This is possibly because it can reduce β-amyloid in brain tissue,increase levels of SOD,and decrease MDA levels; thus to repair brain tissue damage.