稳心颗粒对冠心病合并血脂紊乱患者血清Cys-c和Hcy水平的影响及其临床意义

The Effect of Wenxin Granules on Serum Levels of Hcy and Cys-C in Patients with Coronary Heart Disease and Dyslipidemia and its Clinical Significance

目的:观察稳心颗粒对冠心病合并血脂紊乱患者血清Cys-c和Hcy水平的影响,并探讨其临床指导意义。方法:选择本院心血管科2013年10月至2014年10月的120例冠心病合并血脂紊乱患者作为研究对象,采用随机数字法,随机分为2组,治疗组(n=60例)对照组(n=58例)。对照组采用西医常规基础治疗,治疗组在对照组治疗的基础上加用口服稳心颗粒治疗,9 g/次,冲服,3次/d,2组均治疗4周为1疗程,共治疗2个疗程后比较2组患者治疗前后血清Cys-c和Hcy水平变化及冠脉狭窄程度变化的差异。结果:经2个疗程治疗后,治疗组总有效率93.33%明显高于对照组的81.67%,差异具有统计学意义(P<0.05);并且2组患者的血清Cys-c和Hcy水平亦均有不同程度所下降,而以治疗组下降更为显著,差异具有统计学意义(P<0.05);此外2组患者的冠脉狭窄程度与治疗前比较,总体上也均有不同程度改善(P<0.05),而治疗组的冠脉狭窄改善程度明显优于对照组(P<0.05)试验过程中2组均未见到明显的不良反应。结论:稳心颗粒治疗冠心病合并血脂紊乱能够有效改善患者的冠脉狭窄程度,降低血清Cys-C和Hcy的水平,临床疗效高,不良反应发生率低,值得临床推广应用。

Objective： To observe the effect of Wenxin granules on Cys-c serum and Hcy levels in patients with coronary artery disease and lipid disorders and the clinical efficacy of Wenxin granule. Methods： To select 120 patients enrolled ino our hospital from October 2013 to October 2014,then randomly divided them into two groups： the observation group（ n = 60） and the control group（ n = 58）. Patients in the control group were treated with conventional western medicine and the observation group were treated with Wenxin granules on the basis of conventional western medicine,9 g / a time,taken with water,3 times / d. Both groups were treated for 2 courses,each course 4 weeks. Before and after treatment,changes in serum Cys-c,Hcy levels and the degree of coronary stenosis were compared. Results： After two courses of treatment,the total efficiency in the observation group（ 93. 33%）was significantly higher than that of the control group（ 81. 67%）,and the difference was statistically significant（ P〈0. 05）. Besides,serum Cys-c and Hcy levels of two groups both declined,while the observation group decreased more significantly,and the difference was statistically significant（ P〈0. 05）. In addition,coronary stenosis in the two groups also improved（ P〈0. 05）,and the observation group performed better than the control group（ P〈0. 05）. No significant adverse reactions have been seen. Conclusion： Wenxin granule has obvious efficacy in treating coronary artery disease. It can improve the patient＇s coronary artery stenosis situation,lower serum Cys-c and Hcy levels,has high clinical efficacy and low incidence of adverse reactions. It is worthy of clinical application.