2型糖尿病患者颈动脉内膜中层厚度与IL-1β、IL-18水平的相关性

Relativity between interleukin-1β,interleukin-18 and carotid artery intima-media thickness in type 2 diabetes

目的探讨2型糖尿病（T2DM）患者颈动脉内膜中层厚度（IMT）与IL-1β、IL-18水平之间的相关性,并讨论其作用机制。方法收集本院2013年6月-12月2型糖尿病患者126例,并根据华盛顿大学颈动脉粥样硬化（AS）斑块的超声分级0级-3级分别分为A、B、C、D 4个小组,检测所有患者血清中IL-1β、IL-18浓度,并结合临床资料进行分析。结果 IL-1β、IL-18之间存在明显相关性（r=8.03）;T2DM非合并AS组IL-1β、IL-18浓度明显低于合并AS组,差异有统计学意义（P〈0.05）;T2DM合并AS组中B组IL-1β、IL-18浓度明显高于C组、D组,差异有统计学意义（P〈0.05）,且IL-1β、IL-18浓度与IMT无明显相关性（r值分别为0.217、0.255）。结论 IL-1β、IL-18的分泌和作用具有一定相似性,在AS形成早期作用明显,与IMT并不同步发展。

Objective To investigate the relativity between interleukin- 1β,interleukin- 18 and carotid artery intima- media thickness（ IMT） in type 2 diabetes（ T2DM）,and to discuss the mechanism. Methods 126 T2 DM patients in this hospital were enrolled during June- December in 2013,which were divided into A,B,C,D group according to atherosclerosis plaque ultrasonic classification（ 0- Ⅲ grade） constituted by Washington university; serum IL- 1β,IL- 18 concentrations were detected for further analysis combined with the clinical data. Results There was correlation between IL- 1β and IL- 18（ r =8. 03）; the concentrations of IL- 1β and IL- 18 in T2 DM without AS were lower than the AS group,and the difference was statistically significant（ P〈0. 05）. In T2 DM with AS group,the concentrations of B group were higher than those of C group or D group,and the difference was statistically significant（ P〈0. 05）,besides,there was no evident relationship between IL-1β,IL- 18 and IMT（ r = 0. 217,0. 255,respectively）. Conclusion IL- 1β,IL- 18 are similar on secretion and effect,and the effect is obvious in the early stage of AS,and they express asynchronous development with the IMT.