早期胃癌脉管癌栓相关因素分析

Risk factors of lymphatic or blood vascular tumor emboli in early gastric cancer

目的分析早期胃癌发生脉管癌栓的相关因素。方法回顾性分析了2012年1月至2015年8月的161例早期胃癌患者的临床及病理资料。结果161例早期胃癌患者中有19例存在脉管癌栓，脉管癌栓阳性率为11．80％（19／161）。T1b早期患者脉管癌栓阳性率高于T1a患者，差异有统计学意义（P〈0．01）；有淋巴结转移的早期胃癌患者脉管癌栓阳性率高于无淋巴结转移患者．差异有统计学意义（P〈0.01）。logistic多因素回归分析显示肿瘤浸润深度（OR=6.691，P〈0．05，95％CI：1436～31．170）和淋巴结转移（OR=3138，P〈0.05，95％6／：1．293～7．615）均为早期胃癌发生脉管癌栓的独立影响因素。结论早期胃癌患者发生脉管癌栓主要与肿瘤浸润深度和是否伴有淋巴结转移有密切关系。

Objective To analyze the risk factors of lymphatic or blood vascular tumor emboli in early gastric cancer （EGC）. Methods Clinical and pathological data of 161 patients with early gastric cancer receiving radical resection from January 2012 to August 2015 were retrospectively reviewed. Results Lymphatic or blood vascular tumor emboli were found in 19 out of 161 patients （11.80%）. The incidence of tumor emboli in T1b EGC patients was significantly higher than that in T1a patients （P〈0.01）; and the incidence in patients with lymph node metastasis was significantly higher than that in patients without lymph node metastasis（P〈 0.01）. Multivariate logistic regression showed that the depth of invasion （OR=6.691, 95%CI：1.436~31.170, P〈0.05） and lymph node metastasis （OR=3.138, 95%C/： 1.293-7.615, P〈0.05） were the independent risk factors for lymphatic or blood vascular tumor emboli in early gastric cancer. Conclusion The incidence of vascular tumor emboli is correlated with depth of infiltration and lymph node metastasis in patients with early gastric cancer.