复方氨基酸对肝硬化患者肝功能及AFP、CA199和CEA水平的影响

Effect on Liver Function and AFP, CA199 and CEA Levels by Amino Acid in Patients with Liver Cirrhosis

目的:探讨复方氨基酸对肝硬化患者肝功能以及甲胎蛋白(Alpha fetal protein,AFP)、糖类抗原19-9(Carbohydrate antigen19-9,CA199)、癌胚抗原(Cancer embryo antigen,CEA)水平影响。方法:选取我院消化科收治的肝硬化患者98例,根据治疗方法的不同分为两组。对照组予以常规保肝治疗,实验组在对照组的基础上予以复方氨基酸注射液治疗。比较两组患者治疗1周及2周后的肝功能以及AFP、CA199及CEA水平的变化情况。结果:与对照组比较,实验组的临床疗效较高(87.04%Vs 72.22%),(P<0.05)。与对照组比较,治疗一周后实验组ALT水平较低(195.37±13.42 U/L Vs 154.72±13.44 U/L)、AST水平较低(323.41±21.33 U/L Vs 233.55±21.63 U/L),TB水平较低(125.36±4.26 U/L Vs 108.16±6.45 U/L)(P<0.05),治疗两周后,实验组ALT水平较低(124.28±15.84 U/L Vs 78.53±12.55U/L)、AST水平较低(147.15±13.56 U/L Vs 83.42±20.88 U/L),TB水平较低(92.82±9.64 U/L Vs 56.32±7.43)(P<0.05)。结论:复方氨基酸能够影响肝硬化患者肝功能,改善患者的临床症状,提高临床疗效。

Objective： To investigate the effect of amino acid on liver function and AFP, CA199 and CEA levels in patients with liver cirrhosis. Methods： 98 patients with liver cirrhosis from our hospital were selected and divided into the control group were treated by routine treatment and the experiment group were treated on the base of the control group with the Amino Acid Compound Injection. The liver function, AFP, CA199 and CEA levels were compared in 1 weeks and 2 weeks after treatment. Results： Compared with the control group, the clinical curative effect were higher（87.04% Vs 72.22%）,（P〈0.05）, the ALT level after treatment a week were lower（195.37±13.42 U/L Vs 154.72±13.44 U/L）,（P〈0.05）, the AST level were lower（323.41±21.33 U/L Vs 233.55±21.63 U/L）,（P〈0.05）, the TB level were lower（92.82±9.64 U/L Vs 56.32±7.43）,（P〈0.05）. Compared with the control group, the ALT level after treatment a week were lower（124.28±15.84 U/L Vs 78.53±12.55 U/L）,（P〈0.05）, the AST level were lower（147.15±13.56 U/L Vs83.42±20.88 U/L）,（P〈0.05）, the TB level were lower（92.82±9.64 U/L Vs 56.32±7.43）,（P〈0.05）. Conclusion： Compound amino acids can affect the liver function and CA199, CEA and AFP levels in patients with liver cirrhosis, improve the clinical symptoms and improve the clinical effect.