早发冠脉三支病变患者血清ox-LDL、ApoB及ApoB/A1水平变化及临床意义

Patients with Early Three Coronary Lesions: Changes and Clinical Significance of Serum ox-LDL, Apo B and Apo B/A1

目的:研究早发冠脉三支病变患者血清氧化低密度脂蛋白(ox-LDL)、载脂蛋白B(Apo B)、载脂蛋白A1(Apo A1)及Apo B/A1水平变化及临床意义。方法:选取2014年3月2015年3月我院收治的以心绞痛症状就诊患者185例,根据冠脉造影将患者分为研究组(早发冠脉三支病变103例)和对照组(冠脉正常82例),比较两组ox-LDL、Apo B、Apo A1及Apo B/A1水平,分析其与早发冠脉三支病变的关系。结果:研究组ox-LDL、Apo B及Apo B/A1水平显著高于对照组,两组比较差异具有统计学意义(P<0.05),两组Apo A1水平比较无统计学意义(P>0.05);Logistic回归分析显示:ox-LDL是早发冠脉三支病变的独立危险因素。结论:血清ox-LDL、Apo B及Apo B/A1水平与早发冠脉三支病变密切相关,ox-LDL是独立危险因素。

Objective： To study the changes and clinical significance of serum oxidized low density lipoprotein（ox-LDL）,apolipoprotein B（Apo B） and Apo B/A1 in patients with early three coronary lesions. Methods： A total of 185 patients with angina, who were admitted to Qionghai People＇s Hospital from March 2014 to March 2015, were selected and divided into study group（n=103, with early three coronary lesions） and control group（n=82, with normal coronary） according to the coronary angiography results. The Ox-LDL,Apo B, Apo A1 and Apo B/A1 levels of two groups were compared, and their relationship with early three coronary lesions were analyzed.Results： The Ox-LDL, Apo B and Apo B/A1 levels of study group were significantly higher than those of control group（P〈0.05）, but there was no significant difference in the Apo A1 level between the two groups（P〉0.05）. Logistic regression analysis showed that Ox-LDL was the independent risk factor of early three coronary lesions. Conclusion： The levels of serum ox-LDL, Apo B and Apo B/A1 are closely related with early three coronary lesions, furthermore, Ox-LDL is an independent risk factor.