慢性肝病患者甲状腺功能及性腺功能的变化及意义

Significance of changes in thyroid and gonadal function in patients with chronic liver diseases

目的:研究慢性肝病男性患者甲状腺及性腺功能的变化及与肝病严重程度的关系.方法:应用化学发光法测定162例慢性肝病男性患者的甲状腺及性腺激素水平,慢性肝病患者根据有无肝硬化分为肝硬化组及非肝硬化组,肝硬化的严重程度依据Child-Pugh标准分为A、B、C级,比较各组患者的甲状腺及性腺激素水平.结果:约13%的慢性肝病患者存在甲状腺激素水平的异常.慢性肝病患者的血清TT3,FT3水平显著低于正常对照(1.73 nmol/L±0.38 nmol/L vs 2.59 nmol/L±0.46 nmol/L;4.09 pmol/L±1.35 pmol/L vs 5.23 pmol/L±1.56 pmol/L,均P<0.01),特别是存在肝硬化的患者,其血清TT3、FT3水平显著低于无肝硬化患者(0.96 nmol/L±0.33 nmol/L vs1.84 nmol/L±0.32 nmol/L;3.02 pmol/L±1.10 pmol/L vs 4.33 pmol/L±1.42 pmol/L,均P<0.01),此外Child-Pugh分级B、C级的肝硬化患者TT3、FT3、TT4、FT4水平显著低于A级患者.42%的慢性肝病患者存在继发性性腺功能减退.慢性肝病患者的血清睾酮水平显著低于正常对照组(4.36 ng/mL±2.12 ng/mL vs 7.85 ng/mL±3.31 ng/mL,P<0.01),雌激素水平显著高于正常对照组(45.53 pg/mL±18.79 pg/mL vs 32.26 pg/mL±12.19 pg/mL,P<0.01),特别是存在肝硬化的患者更为明显,而且与非肝硬化患者比较亦有显著的统计学意义.此外在肝硬化患者中Child-Pugh分级B和C级患者的血清睾酮水平显著低于A级患者,雌激素水平显著高于A级患者.无低T3综合征和性腺功能减退的慢性肝病患者其反映病情严重程度的生化指标如AST,ALT等显著好于存在性腺功能减退的患者.结论:慢性肝病患者存在甲状腺及性腺功能的异常,甲状腺激素及性腺激素水平的测定对评价慢性肝病的严重程度具有一定的价值,可作为判断病情和观察治疗效果及预后的重要依据.

AIM： To investigate the changes in thyroid and gonadal function in patients with chronic liver diseases and to explore the relationship between serum thyroid and gonadal hormone levels and severity of chronic liver diseases.METHODS： Serum thyroid and gonadal hormone levels were measured by chemiluminescence method in 162 male cases with chronic liver diseases. Patients with chronic liver diseases were divided into a cirrhosis group and a non-cirrhosis group, and cirrhosis was graded by Child-Pugh score（A, B, C）.RESULTS： Thyroid dysfunction was present in ~13% of patients with chronic liver diseases. Serum total T3 and free T3 levels in patients with chronic liver diseases were significantly lower than those of the control group（1.73 nmol/L ± 0.38 nmol/L vs 2.59 nmol/L ± 0.46 nmol/L, 4.09 pmol/L ± 1.35 pmol/L vs 5.23 pmol/L ± 1.56 pmol/L, P 0.01）. Cirrhotic patients had significantly lower serum total T3 and free T3 levels than non-cirrhotic patients（0.96 nmol/L ± 0.33 nmol/L vs 1.84 nmol/L ± 0.32 nmol/L, 3.02 pmol/L ± 1.10 pmol/L vs 4.33 pmol/L ± 1.42 pmol/L, P 0.01）. Serum total T3, T4 and free T3 and T4 levels in cirrhotic cases with Child-Pugh B or C grade were significantly lower than those of Child-Pugh A grade cases. Chronic liver diseases were more serious in patients with low T3 syndrome than in those without. Approximately 42% of patients with chronic liver diseases hadsecondary gonadal dysfunction. Serum testosterone levels were significantly lower and estrogen levels were significantly higher in patients with chronic liver disease than in the control group（4.36 ng/mL ± 2.12 ng/mL vs 7.85 ng/mL ± 3.31 ng/mL, 45.53 pg/mL ± 18.79 pg/mL vs 32.26 pg/mL ± 12.19 pg/mL, P 0.01）. Serum testosterone levels were significantly lower and estrogen levels were significantly higher in cirrhotic cases with Child-Pugh B and C grades than in Child-Pugh A grade cases. Chronic liver diseases were more serious in patients with secondary gonadal dysfunction than in those without.CONCLUSION： Thyroid and gonadal dysfunction is present in patients with chronic liver diseases, so the determination of thyroid and sex hormones has important value for the evaluation of severity and prognosis of the disease.