重庆市不同地区健康人群麻疹抗体水平监测分析

Analysis on Measles Antibody Level of Healthy People in Different Areas of Chongqing

目的了解重庆市健康人群麻疹抗体水平,评估不同地区免疫现状,提供针对性策略。方法根据重庆市经济发展地域分布特征,将所有区县分为3层,每层随机选取1个区县,每个区县选择6个年龄组,每个年龄组随机抽取30名对象开展血清学检测和问卷调查。结果共收集到540份标本,麻疹Ig G阳性样本(抗体滴度≥200m IU/ml)484份,总阳性率为89.63%,几何平均滴度(GMT)为1:668.90。各年龄组间、地区间抗体阳性率经检验差异有统计学意义。问卷调查结果显示:尚不能认为文化程度、居住状况、家庭年收入、麻疹疫苗知晓率分别对麻疹抗体阳性率结果有影响。结论中小学生麻疹抗体水平较低,存在成人麻疹暴发流行的风险,应加强常规入托入学查验接种证工作与重点人群补充免疫活动,降低免疫空白人群积累。

Objective To learn measles antibody level of healthy people in Chongqing, assess immunization condition in different areas and propose appropriate strategies. Methods According to economic and geographic characteristics, 3 districts were selected by stratified sampling. In each district, 6 age groups with 30 objects in each group were selected to conduct serological test and questionnaire study. Results 540 serums were collected with 484 positive （89.63%） and the antibody geometric mean titer （GMT） was 1：668.90. significant differences were found in the seropositive rate of measles antibody between different districts and age groups. No statistical difference was found between living condition, educational background, family annual income, vaccine awareness rate and measles seropositive rate respectively by chi-square test, Conclusion The measles antibody level was significantly low in primary and secondary school students, strategies like immunization record checking at school entry and SIAs targeting special groups needed to be strengthened in order to reduce accumulation of Susceptibles.