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低剂量阿托伐他汀降脂治疗老年冠心病临床疗效及安全性分析 被引量:1

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摘要 目的研究阿托伐他汀降脂治疗老年冠心病患者的临床疗效及安全性。方法回顾性分析老年冠心病心绞痛患者的临床资料,分为给予阿托伐他汀的观察组和常规治疗的对照组,观察心功能指标、血脂相关指标及不良反应例数。结果观察组ST段抬高程度、甘油三酯、胆固醇、LDL和Apo B水平明显低于对照组;左心室舒张末期直径、射血分数、HDL和Apo A-Ⅰ水平明显高于对照组;不良反应发生例数与对照组无差异。结论阿托伐他汀降脂治疗能够有效改善心功能指标和血脂代谢情况,并且不会引起不良反应增多,是老年冠心病安全、有效的治疗方式。
作者 黄革红
出处 《疾病监测与控制》 2016年第4期330-332,共3页 Journal of Diseases Monitor and Control
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  • 1李建军.他汀类药物治疗急性冠脉综合征的抗炎机制[J].中华老年心脑血管病杂志,2005,7(5):358-360. 被引量:3
  • 2Kwak B, Mulhaupt F, Myit S, et al. statins as a newly recognized type of immunomodulator. Nat Med, 2000, 6(12):1399-1402.
  • 3Weitz-Schmidt G, Welzenbach K, Brinkmann V, et al. Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site. Nat Med, 2001,7 (6):687-692.
  • 4Veillard NR, Braunersreuther V, Arnaud C, et al. Simvastatin modulates chemokine and chemokine receptor expression by geranylgeranyl isoprenoid pathway in human endothelial cells and macrophages. Atherosclerosis, 2006,188(1):51-58.
  • 5Allan MI, Rosario S, David JI. Vascular effects of HMG-CoA reductase inhibitors (statins) unrelated cholesterol lowering: new concepts for cardiovascular disease. Cardiovasc Res,2001,49(3): 281-287.
  • 6Parmar KM, Nambudiri V, Dai G, et al. Statins exert endothelial atheroprotective effects via the KLF2 transcription factor. J Biol Chem, 2005, 280(29):26714-26719.
  • 7Kothe H, Dalhoff K, Rupp J, et al. HMG-CoA reductase inhibitors modify the in flammatory response of human macrophage and endothelial cells infected with Chlamydia pneumoniae. Circulation, 2000,101:1760.
  • 8Clements JD, Jamali F. Pravastatin reverses the down-regulating effect of inflammation on beta-Adrenergic receptors: A diseasedrug interaction between inflammation, pravastatin, and propranolol. Vascul Pharmacol.2007, 46(1):52-59.
  • 9Ridker PM, Rifai N, Stampfer M J, et al. Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation,2000,101:1767-1772.
  • 10Bellosta S, Via D, Canavesi P, et al. HMG-CoA reductase inhibitors reduce MMP-9 secretion by marcophages. Arteroscler Thromb Vasc Biol, 1998, 18:1671.

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