大黄和皮硝治疗右心衰竭所致胃肠功能紊乱的疗效观察

Efficacy of Rhubarb and Natrii Sulfas in Treatment of Right Heart Failure Caused by Gastrointestinal Dysfunction

目的:观察大黄与皮硝在右心衰竭所致胃肠功能紊乱治疗中的应用效果。方法:选取本院2013年1月至2014年12月间的70例右心衰竭所致胃肠功能紊乱患者为研究对象,将其按照随机数字表法分为研究组与对照组,对照组给予常规治疗,研究组在常规治疗上加用大黄与皮硝,观察2组的临床治疗有效率、心功能改善时间、排便时间、排气时间和不良反应的情况进行对比。结果:研究组治疗有效率88.6%,显著的高于对照组治疗有效率的77.1%,二者数据比较差异有统计学意义(P<0.05)。研究组心功能改善时间和排便时间以及排气时间分别为(3.4±0.6)h、(31.6±6.7)h、(36.7±7.8)h;对照组心功能改善时间和排便时间以及排气时间分别为(6.5±1.1)h、(55.8±10.5)h、(64.7±11.8)h;研究组心功能改善时间和排便时间以及排气时间均明显的低于对照组,二组数据比较差异有统计学意义(P<0.05)。治疗前研究组与对照组C反应蛋白(C-reactionprotein,CRP)分别为(88.5±11.5)mg/L、(89.8±10.7)mg/L,治疗后研究组与对照组CRP分别为(20.7±4.7)mg/L、(37.8±7.4)mg/L,治疗前研究组与对照组CRP比较差异无统计学意义(P>0.05);治疗后2组CRP均较治疗前有明显的降低,且研究组降低程度优于对照组,差异有统计学意义(P<0.05)。结论:右心衰竭所导致的胃肠功能紊乱在常规治疗基础上加用大黄与皮硝效果显著,缩短肛门排便、排气时间,改善心功能,且无不良反应,安全性高,值得临床中应用与推广。

Objective： To observe the efficacy of rhubarb and natrii sulfas in the treatment of right heart failure due to gastrointestinal disorders. Methods： Right heart failure caused by gastrointestinal dysfunction patients of 70 cases in the hospital from 2013-01 to 2014-12 were included in this study and randomly divided into study group and control group,the control group received conventional therapy while the study group were treated with rhubarb and natrii sulfas based on the conventional therapy. Clinical effective rate,cardiac function improvement time,defecation and exhaust time and adverse reactions of the two groups were compared. Results： Effective rate of the study group was 88. 6%,significantly higher than 77. 1% of the control group,the data had statistically significant difference（ P〈0. 05）. Cardiac function improvement time,defecation time and exhaust time of the study group were（ 3. 4 ± 0. 6） h,（ 31. 6 ± 6. 7） h,（ 36. 7 ± 7. 8） h respectively; those of the control group were（ 6. 5 ± 1. 1） h,（ 55. 8 ±10. 5） h,（ 64. 7 ± 11. 8） h; those indexes of the study group were significantly lower than the control group（ P〈0. 05）. Before treatment,the CRP of study group and the control group were respectively（ 88. 5 ± 11. 5） mg / L and（ 89. 8 ± 10. 7） mg / L;after treatment,the CRP of study group and the control group CRP were（ 20. 7 ± 4. 7） mg / L,（ 37. 8 ± 7. 4） mg / L,without significant differences（ P〈0. 05）; after treatment,the CRP of the two group significantly reduced,but the study group had lower level than the control group,the difference was statistically significant（ P〈0. 05）. Conclusion： the efficacy of rhubarb and natrii sulfas in the treatment of right heart failure due to gastrointestinal disorders is significant with reduced defecation and exhaust time and improved cardiac function,no adverse reaction and good safety. It is worthy of clinical adoption.