c-Abl与实体瘤关系研究进展

Research progress of the relationship between c-Abl and solid tumors

非受体型酪氨酸激酶c-Abl具有多种生物学功能,可参与细胞周期、细胞迁移、细胞凋亡、DNA应激损伤反应修复等重要生命过程的调控,其过度激活与慢性粒细胞白血病的发生、发展密切相关,且在白血病方面的研究详细深入,但在实体瘤研究方面则刚刚起步,文章就c-Abl在实体瘤方面的研究进展进行简要综述.

Non-receptor tyrosine kinase c-Abl has been implicated in the regulation of the cell cycle,adhesion, apoptosis and DNA damage responses.Its excessive activation is related with the development of chronic myeloid leukemia, and the relationship between c-Abl and leukemia is in depth and detailed research.In contrast to leukemia, the research between c-Abl and solid tumors is just at the early stage.This paper briefly reviews research progress of the c-Abl in solid tumors.