摘要
钠碘共同转运体(sodium iodide symporter,NIS)是甲状腺激素合成过程中转运碘的糖化膜蛋白,调控甲状腺细胞摄取碘,是甲状腺及其转移癌进行放射性碘治疗的基础。研究显示放射性碘对乳腺癌也有治疗作用,乳腺癌能表达NIS蛋白,研究NIS在乳腺癌中的作用机制并进行干预,可能成为治疗乳腺癌的潜在靶点,NIS介导放射性碘可能是治疗乳腺癌尤其是三阴性乳腺癌的一个新的方向。
Sodium iodide symporter（NIS） is a glycosylated membrane protein in the process of thyroid hormone synthesis,and NIS regulates iodine uptaken of thyroid cells,which is the basis for the treatment of radioactive iodine in thyroid and its metastatic carcinoma. Studies have shown that radioactive iodine also has therapeutic effect on breast cancer. It has been reported that breast cancer can express NIS protein. To study the mechanism and intervention of NIS in breast cancer may become the potential target of treatment for breast cancer,NIS mediated by radioactive iodine may be a new direction for the treatment of breast cancer,especially three negative breast cancer.
出处
《中国肿瘤》
CAS
2016年第4期282-285,共4页
China Cancer
关键词
钠碘共同转运体
乳腺癌
放射性碘
sodium iodide symporter（NIS）
breast cancer
radioactive iodine
