促排卵期间小剂量阿司匹林对子宫内膜发育的影响

Effect of low-dose aspirin on endometrial development in ovulotropic period

目的观察促排卵期间小剂量阿司匹林对子宫内膜发育的影响。方法收集50例因排卵功能低下不孕女性患者,随机分为研究组与对照组,每组各25例。对照组采用克罗米芬治疗,研究组在克罗米芬治疗的基础上加用阿司匹林(100 mg/d)。结果排卵前1 d,研究组的TXA2水平(51.48±12.25)ng/L与TXA2/PGI2比值(0.59±0.23)均显著低于对照组[(90.60±16.29)ng/L,1.24±0.37],差异均有统计学意义(P<0.05)。研究组排卵前后的子宫内膜厚度[(0.92±0.16)cm,(1.02±0.19)cm]均明显高于对照组[(0.72±0.18)cm,(0.80±0.16)cm],差异均有统计学意义(P<0.05)。与对照组对比,研究组排卵前1 d的子宫动脉血流RI(0.81±0.05)明显更低(P<0.05);排卵后10 d,两组RI值无统计学差异。研究组排卵后10 d的子宫内膜面积、间质面积、腺腔周长及腺/间比值、子宫内膜ER和PR均明显高于对照组(P<0.05)。结论在促排卵期间,采用小剂量阿司匹林治疗有利于增加子宫血流供应,能有效促进子宫内膜发育、增厚,利于妊娠。

Objective To study the effect of low-dose aspirin on endometrial development in ovulotropic period. Methods50 female patients with infertility due to ovulatory dysfunction were divided into study group and control group,25 patients each. The control group received clomiphene treatment where as the study group took aspirin（ 100 mg / d） and clomiphene. Results 1 d before ovulation,TXA2level（ 51. 48 ± 12. 25） ng / L and TXA2/ PGI2ratio（ 0. 59 ± 0. 23） in the study group were significantly lower than in the control group [（ 90. 60 ± 16. 29） ng / L,1. 24 ± 0. 37],with statistically significant difference（ P〈0. 05）; endometrial thickness before and after ovulation the in study group [（ 0. 92 ± 0. 16） cm,（ 1. 02 ± 0. 19 cm） ]were significantly higher [（ 0. 72 ± 0. 18） cm;（ 0. 80 ± 0. 16） cm]（ P〈0. 05）; and in control group,1 d before ovulation,uterine artery RI（ 0. 81 ± 0. 05） was significantly lower（ P〈0. 05）; 10 d after ovulation,RI values in the two groups had no significant difference; compared with the control group,in the study group,10 d after ovulation,endometrial area,interstitial area,luminal and glandular perimeter / room ratio,endometrial ER and PR were significantly higher（ P〈0. 05）. Conclusions During ovulation,low-dose aspirin therapy helps increase blood supply to the uterus,can effectively promote the development of endometrial thickeness,and help improve the pregnancy rate.