活血化瘀通络法联合针刺治疗对糖尿病下肢血管病变的影响

Effect of Promoting Blood Circulation and Removing Blood Stasis Combined with Acupuncture on Diabetic Lower Extremity Arterial Disease

目的:探讨活血化瘀通络法联合针刺辅助治疗对糖尿病下肢血管病变(DLEAD)影响。方法:收集我院DLEAD患者90例,随机分为实验组1、实验组2和对照组。对照组予DLEAD基础治疗。实验组1在对照组基础上予以活血化瘀法中药治疗。实验组2在实验组1基础上加针刺治疗。对三组患者治疗前、治疗后进行FBG、P2h BG、Hb Alc测定,血清IL-6、ET-1水平测定及PAg T%、踝肱指数ABI测定。结果:1治疗后三组FBG、P2h BG、Hb Alc均下降,两组实验组较对照组均改善更明显,且实验组2下降更明显,差异有统计学意义(P<0.05);2治疗后三组IL-6、ET-1及PAg T%均下降,两组实验组均比对照组改善更明显,实验组2下降更明显,差异有统计学意义(P<0.05);3治疗后三组ABI均有所改善,两组实验组均更明显改善,且实验组2 ABI上升更明显,差异有统计学意义(P<0.05)。结论:活血化瘀联合针刺治疗,可调节血清IL-6、ET-1水平,降低PAg T%,改善ABI,可有效提升DLEAD患者临床疗效,改善其预后,对提高患者生活质量有重要意义。

Objective： To investigate the effect of promoting blood circulation and removing blood stasis combined with acupuncture on diabetic lower extremity arterial disease（DLEAD）. Methods： 90 cases with DLEAD patients from our hospital were selected and randomly divided into the control group, the experimental group1 and the experimental group 2. The control group was treated with DLEAD basic therapy. The experimental group1 were treated with treatment of Chinese medicine for activating blood circulation and removing blood stasis on the base of the control group. The experimental group 2 were treated with acupuncture on the base of the experiment group1. The FBG, P2 h BG, Hb Alc, serum IL-6, ET-1 level and PAg T %, ABI were tested and compared before and after treatment.Results： Compared with before treatment, the FBG, P2 h BG and Hb Alc were lower after treatment（P〈0.05）, more obviously in the two experimental group than the control group（P〈0.05）, and it was obviously lower in experimental group 2 than that of the experimental group1（P〈0.05）. Compared with before treatment, the serum IL-6, ET-1 level and PAg T % were decreased after treatment（P〈0.05）,more obviously in experimental group than the control group（P〈0.05）, and it was obviously lower in experimental group 2 than that of group1（P〈0.05）. Compared with before treatment, the ABI were better（P〈0.05）, and the experimental group was superior to control group（P〈0.05）, and the experimental group2 was superior to group1（P〈0.05）. Conclusions： The Chinese medicine of promoting blood circulation and removing blood stasis combined with acupuncture can adjust serum level of IL-6 and ET-1, reduce PAg T %, improve ABI, and effectively improve the clinical curative effect of DLEAD patients, improve the prognosis and the quality of life of patients.