LincRNA的研究进展

Research Progress of LincRNA

基因间长链非编码RNA(large intergenic non-coding RNA,linc RNA)是指基因间不编码蛋白质的长度大于200nt的RNA。最初,linc RNA被认为是基因组转录的"噪声",不具备任何生物学功能。然而,随着第二代测序技术的发展及其所产生的大量数据,越来越多的linc RNA被识别,引起了人们的重视。至今,已有超过12000的linc RNAs被收录在人类基因组中。随着研究的深入,linc RNA的生物机制和潜在的一些功能越来越明朗。本篇综述总结了近年来linc RNA的研究历程,序列特征,疾病中发挥的作用以及相关数据库的分析。

Large intergenic non-coding RNAs（linc RNAs） refer to intergenic non-coding RNAs whose lengths are more than200 nt. Initially linc RNA was considered to be ＂noise＂ in the genomic transcription. However, since the development of second-generation sequencing technology and a large amount of data generated by sequencing technology, the growing number of linc RNAs are identified, causing people＇s attention. There are more than 12,000 linc RNAs included in the human genome. With deep research, biological mechanisms and potential features of linc RNAs become clear. This review summarized the research progress about linc RNAs, sequence characters, roles played in diseases and relevant databases.