自拟活血通络方治疗冠心病PCI术后心绞痛

Huoxue Tongluo treatment on percutaneous coronary intervention postoperative angina pectoris of coronary heart disease

目的评价自拟活血通络方治疗冠心病经皮冠状动脉介入术(PCI)术后心绞痛的有效性及安全性。方法选择80例PCI术后心绞痛患者,采用随机数字表将研究对象分为对照组40例,给予冠心病PCI术后西医规范化抗心绞痛治疗;治疗组40例,在对照组治疗的基础上加服活血通络方水煎剂200 m L/次,2次/d,观察心绞痛发作次数及持续时间、24 h动态心电图变化、中医临床证候积分变化、短期预后及不良反应。结果 2组治疗后心绞痛发作次数、持续时间均明显减少,差异有统计学意义(P<0.01);治疗组心绞痛持续时间缩短更为明显(P<0.05)。2组治疗后心电图缺血发作次数、缺血总时间、缺血最长持续时间、室性早搏个数均减少(P<0.05),治疗组改善更为显著(P<0.05)。治疗后2组中医证候积分均下降(P<0.05),治疗组患者下降幅度明显大于对照组(P<0.05)。治疗组短期预后优于对照组(P<0.05)。结论在西医规范化抗心绞痛治疗基础上采用活血通络方治疗冠心病PCI术后心绞痛可提高临床疗效,改善短期预后。

Objective To evaluate the efficacy and safety of Huoxue Tongluo in the treatment of PCI postoperative angina pectoris of coronary heart disease. Methods By using random numbers table,the research subjects were randomly divided into normal group of 40 cases,give the PCI postoperative standardized treatment of coronary heart disease,the treatment group 40 cases,on the basis of the standard treatment with Huoxue Tongluo,200 ml / t,2 times /d. Results The frequency and time of angina were better than before treatment in both groups（ P〈0. 01）; Treatment group angina pectoris duration is more obvious（ P〈0. 05）. 24 hours dynamic electrocardiogram ischemia attack number of times,total time,ischemia for the longest time,the total number of ventricular premature were significantly decreased,showing statistical difference when compared with the group before treatment（ P〈0. 05）,treatment group decreased more significantly than the conventional group after treatment（ P〈0. 05）. Declined scores of clinical chinese medical syndrome were significantly decreased,showing statistical difference when compared with the group before treatment（ P〈0. 05）,treatment group decreased more significantly than the conventional group after treatment（ P〈0. 05）. The treatment group short-term prognosis is better than that of control group（ P〈0. 05）. Conclusion On the basis of standardized treatment with Huoxue Tongluo can improve the clinical curative effect,improve the short-term prognosisand,found no adverse reactions in the treatment of PCI postoperative angina pectoris of coronary heart disease.