时疫病用药规律研究

Regularity of treating epidemic disease

目的挖掘古代医家治疗时疫病的用药经验。方法运用文献学和文本挖掘的基本方法,以文献古籍为研究基础和资料来源,采用信息学技术和知识发现技术,对文献史料中关于时疫病的记载文献加以收集、整理和挖掘。结果检索到相关文献1 114条,涉及302 682字,记载了192种用以防治时疫病的常用中药,中药使用的总频数为5 679次。常用的中药包括柴胡、人参、黄芩和甘草,药对以桔梗与甘草、柴胡与甘草等为主,语义网络研究也发现这几种药的配伍非常常用,是治疗时疫病的核心药物组合,药性方面多选用药性寒凉、辛味及或苦或甘味的中药,而且以归肺脾心肝等经的药为主;功效方面,以发散功效和清热类中药最多,而补气药也不少,此外利湿和活血的药亦可见。结论总体来看,以《伤寒论》中的经方配伍用药为主,多为驱邪、补益扶正、和解之品,以达到扶正祛邪的效果,切合《内经》正气存内,邪不可干之旨,又不离《伤寒》大宗,值得临床用药参考。

Epidemic disease is highly contagious,equivalent to modern medicine,infectious diseases,prevention and treatment with traditional Chinese medicine when the disease has certain advantages,the ancient physicians accumulated very rich clinical experience in prevention and treatment of plague,basically formed a relatively rich and unique theoretical system of epidemic disease prevention and control,as the medication experience blight mining of ancient physicians,basic methods this thesis research work will use literature and text mining,the basis of the study and sources of data for science and technology in ancient documents,the information used to collect,collate,and mining of historical documents about disease in literature. The retrieval of relevant documents 1113,involving 302682 words,records of the 192 to control disease of traditional Chinese medicine,the total frequency of use Chinese medicine for 5679 times. Commonly used traditional Chinese medicine including bupleurum root,ginseng,Radix Scutellariae and licorice,licorice,Campanulaceae and medicine for bupleurum root and licorice primarily,semantic web research also found that the compatibility of these drug is very commonly used,is the core of drug combination therapy of traditional Chinese medicine disease,multi selection of resistance to cold,pungent taste or bitter or sweet,and mainly to the lung spleen heart through drug; efficacy,with divergent effect and heat clearing drugs most,and qi invigorating drugs also many,moreover dampness and blood activating medicine also many. Overall,the conclusion is given priority to with the party compatibility of medicines in Treatise on Febrile Disease,exorcism tonic medicine centralizer,supporting reconciliation in order to achieve the effect of,suit a vital qi in The Internal Canon of Medicine,the pathogenic qi did not invade the health body,and from Typhoid Fever of commodities,is worth reference for clinical application.