参七抗癌散抗肿瘤及其镇痛作用

Anti-Tumor and Analgesic Effects of Shenqi Powder

目的:阐释参七抗癌散医院制剂抗肿瘤和镇痛的药效作用,为其临床疗效提供现代药理实验依据。方法:采用溶剂法将参七抗癌散提取分离为不同化学物质部位,通过MTT法筛选该复方制剂抗肿瘤有效物质部位;采用扭体法和热板法,对参七抗癌散提取物进行了小鼠镇痛实验研究。结果:参七抗癌散的氯仿萃取物能明显抑制肺腺癌A549细胞,确定为该制剂抗肿瘤有效物质部位;参七抗癌散能减少小鼠扭体反应数,能延长小鼠疼痛反应的潜伏期。结论:参七抗癌散具有明显抗肿瘤和镇痛的生物活性。

Objective：To study the anti-tumor and analgesic efficacy of the hospital preparation Shenqi powder,a trational Chinese anti-tumor medicine,and provide modern pharmacological experiments basis for its clinical efficacy.Methods：Solvent method was used in the experiment to extract and separate for different parts fromShenqi powder.MTT assay was used to screen the antitumor compound recipe for screening effective anti-tumor parts;The analgesic effect of Shenqi powder was determined by writhing test and hot plate test in mice.Results：The chloroform extract fromShenqi powder had obvious cytotoxicity on lung cell A549,and it was determined as the effective anti-tumor part;Shenqi powder significantly inhibited the writhing times induced by acetic acid and threshold of pain.Conclusion：Shenqi powder has anti-tumor and analgesic biological activity.