组织工程气管软骨种子细胞的研究进展

Research Progress in Seed Cells of Tissue Engineered Tracheal Cartilage

理想气管替代物的缺乏制约了较大范围气管病损的外科治疗,阻碍了气管外科的发展。组织工程技术的兴起与发展,为气管病损的修复提供了新的途径,成为了除自体组织、同种异体组织、人造气管移植外最为理想的治疗方法。气管软骨作为气管的支撑性结构,其构建是组织工程气管研究的基础。因此,作为构建组织工程气管软骨的软骨种子细胞对于成功构建组织工程气管极其重要。本文通过组织工程气管构建因素、软骨种子细胞的分类、各类软骨种子细胞在组织工程气管研究中的应用及其优劣势等方面对组织工程气管软骨种子细胞的研究进行综述。

The lack of good alternatives of trachea restricted the surgical treatment of a wide range of tracheal lesions,and hindered the development of tracheal surgery.The rise and development of tissue engineered technology,a more ideal treatment method except autograft,allograft and transplantation of artificial trachea,had provided a new way for the repair of tracheal lesions.The constructing of tracheal cartilage,which was the supporting structure of trachea,was the basis for the research of tissue engineered trachea.Therefore,seed cells of cartilage,which would be applied to construct tissue engineered tracheal cartilage,were extremely important for the successful construction of tissue engineered trachea.This article would review such research progress in seed cells of tissue engineered tracheal cartilage from factors of constructing tissue engineered trachea,classification in seed cells of cartilage,the applications,the advantages and disadvantages of all kinds of seed cells of cartilage in the research of tissue engineering trachea.