MicroRNA在多囊卵巢综合征中的表达及作用

Expression and Effect of MicroRNA in Patients with Polycystic Ovary Syndrome

非编码微小RNAs(microRNAs,miRNAs)主要在转录后水平上调控基因表达,异常miRNA表达与胰岛素抵抗、糖尿病、炎症及各种癌症形成有关。多囊卵巢综合征(polycystic ovary syndrome,PCOS)患者血清及卵泡液中miRNAs表达谱存在差异,其异常的miRNAs表达能够通过影响基因转录后水平,参与PCOS的发生发展。综述miR-93、miR-222、miR-92a/b、miR-224、miR-320、miR-9、miR-483-5p、miR-513a-3p、miR-24、miR-133b、miR-26b和miR-378在PCOS患者的胰岛素抵抗、性激素合成和分泌、颗粒细胞增生、卵泡发育异常及排卵障碍中的作用,探讨miRNA在PCOS发病机制中的作用。

Non-coding microRNAs（microRNAs,miRNAs） are able to regulate the expression of target genes at the post-transcriptional level. Altered miRNA levels are associated with the pathological development of diabetes,insulin resistance,inflammation and various cancers. The miRNAs profiles express differently in the serum and follicular fluid of women with polycystic ovary syndrome（PCOS）. Altered miRNA levels may participate in the development of PCOS. Here,we summarize the effects of miR-93,miR-222,miR-92a/b,miR-224,miR-320,miR-9,miR-483-5p,miR-513a-3p,miR-24,miR-133 b,miR-26 b and miR-378 in insulin resistance,steroid hormone synthesis and secretion,granule cell proliferation,follicular development dysplasia and ovulation disorder in PCOS patients,so as to explore the roles of miRNAs in the pathogenesis of PCOS.