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α-酮戊二酸二甲酯抑制乳腺癌细胞增殖的机制研究 被引量：1

Mechanism of inhibition of breast cancer cell proliferation by α-dimethyl 2-oxoglutarate
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摘要 α-酮戊二酸二甲酯（DM-2KG）是目前在基础研究中广泛被应用为养料来营救因营养缺失导致的细胞生长抑制[1].据报道,在多种代谢酶发生突变如IDH1或SDH突变的肿瘤细胞中,当应用DM-2KG干预后,这类代谢物进入细胞后即可转化为PHD活化的辅助因子α-KG,激活PHD酶活性,促进缺氧诱导因子-1α（HIF-1α）蛋白降解[2],即HIF-1α蛋白的PHD经典降解途径。
作者 侯培锋 陈强
机构地区 福建医科大学干细胞医学研究院福建省肿瘤转化医学重点实验室福建医科大学附属协和医院肿瘤内科
出处 《中国药理学通报》 CAS CSCD 北大核心 2016年第5期738-739,共2页 Chinese Pharmacological Bulletin
基金 福建省卫计委医学创新项目(No 2015-CXB-15)
关键词 α-酮戊二酸类似物 缺氧诱导因子-1Α 静止期细胞 乳腺癌干细胞 脯氨酰羟化酶2 靶点 DM-2KG HIF-1α quiescent cell breast cancer stem cell PHD2 target
分类号 R329.24 [医药卫生—人体解剖和组织胚胎学] R737.902.2 [医药卫生—肿瘤]
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  • 1LinTC,ChenYR,KensickiE,etal.Autophagy:resettingglu-tamine-dependentmetabolismandoxygenconsumption[J].Auto-phagy,2012,8(10):1477-93.
  • 2MacKenzieED,SelakMA,TennantDA,etal.Cell-permeatingα-ketoglutaratederivativesalleviatepseudohypoxiainsuccinatede-hydrogenase-deficientcells[J].MolCellBiol,2007,27(9):3282-9.
  • 3HouP,KuoCY,ChengCT,etal.Intermediarymetabolitepre-cursordimethyl-2-ketoglutaratestabilizeshypoxia-induciblefactor-1αbyinhibitingprolyl-4-hydroxylasePHD2.[J].PLoSOne,2014,9(11):113865.
  • 4张梅,袁霞,徐波,冉福香,吴军,葛泽梅,李润涛,崔景荣.蛋白酶体抑制剂YSY01A不依赖NF-κB通路抑制乳腺癌细胞增殖及诱导凋亡研究[J].中国药理学通报,2014,30(3):34-39. 被引量：2

二级参考文献12

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中国药理学通报
2016年 第5期

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