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阿托伐他汀诱导肝脏Cyp7a1和时钟基因的表达 被引量:1

Atorvastatin induces hepatic expression of Cyp7a1 and Bmal1 and Clock in mice
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摘要 他汀类药物是羟甲戊二酰辅酶A(HMGCR)选择性抑制剂,是临床防治冠心病的重要药物[1-2].研究表明,阿托伐他汀能升高肝脏中胆固醇7羟化酶(Cyp7a1)的表达,改变体内胆汁酸代谢[3],并可能与其长期使用所致肝脏不良反应有关[4].
出处 《中国药理学通报》 CAS CSCD 北大核心 2016年第5期739-740,共2页 Chinese Pharmacological Bulletin
基金 国家自然科学基金资助项目(No 81160415)
关键词 阿托伐他汀 安全性 胆汁酸代谢 CYP7A1 生物钟 BMAL1 Cloc atorvastatin safety bile acid metabolism Cyp7a1 circadian rhythm Bmal1 Clock
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