SLA种植体表面喷涂钽形成纳米复合表面预防种植术后早期感染的动物体内实验研究

The influence of two different types of surface modification with implants in experimental periimplantitis

目的探讨大颗粒酸蚀喷砂（Sandblasted/Large-grit/Acide-tched,SLA）表面处理的种植体与SLA表面喷涂钽（Ta）形成纳米复合表面的种植体对种植体周围炎发生发展的影响。方法 6只Beagle犬双侧前磨牙延期植入2种不同表面种植体。从左侧远中到右侧远中依次将植体记为1~6号,3、4号种植体设置非绑线的基线组,其余于基台颈部丝线结扎的方法建立犬种植体周围炎模型。分别在建模后四次对植体进行菌斑指数（plaque index,PI）、改良出血指数（modified Sulcus Bleeding Index,m SBI）、种植体周探诊深度（probing depth,PD）等临床指标测量,通过手术直观评价、显微CT扫描、组织学评价相结合观察种植体周骨缺损程度,对实验结果采用重复测量方差分析。结果绑线的SLA组PI、m SBI、PD、垂直缺损与水平缺损深度等指标均显著高于绑线的SLA＋Ta组（P〈0.05）;显微CT扫描和组织学评价相结合观察可见绑线的SLA组较绑线的SLA＋Ta组种植体周骨缺损明显。结论 SLA表面喷涂钽形成纳米复合表面的种植体较SLA表面处理的种植体延缓种植体周围炎的发生发展并减轻其症状。

Objective To explore the influence of the occurance and development of experimental peri- implantitis between Sandblasted/Large- grit/Acide- tched（SLA） surface and nanoporous tantalum（Ta）-incorporated Sandblasted/Large- grit/Acide- tched（SLA） surface. Methods Two types of implants with different surface modification were implanted in the mandible of 6 Beagle dogs after the extraction of mandibular premolars. After prosthesis-abutment connection, suture line was twined to the neck of abutment in the experimental group, while there＇s no suture in the control group. The implants were recorded sequentially from left to right of the distal as 1~6; 3、4 served as the control group while others served as the experimental group. Clinical indicators like plaque index, modified Sulcus Bleeding Index and probing depth were measured for 4 times. Micro-CT scan, surgical recording and pathological changes of peri-implant bone morphology were studied. MANOVA of repeated measuring was used. Result There were significant differences（P〈0.05） for plaque index, modified Sulcus Bleeding Index and probing depth and surgical measurement between SLA ＋ Ta twined with the suture group and SLA twined with the suture group, the degree of inflammation for SLA＋Ta twined with the suture group were inferior to SLA twined with the suture group. Conclusion Implants with nanoporous tantalum（Ta）- incorporated Sandblasted/Large- grit/Acide-tched（SLA） surface shows postponed occurrence and development of peri-implantitis than Sandblasted/Largegrit/Acide-tched,（SLA） surface implants and can relieve the degree of inflammation.