Nrf2-ARE信号通路在机体氧化应激损伤中的作用及与其他信号通路的关系

Role of Nrf2-ARE Pathway in Oxidative Stress Injury and Its Relationship with Other Signaling Pathways

氧化应激损伤与机体中多种疾病的发生与发展过程密不可分,当机体产生严重氧化应激时,抑制氧化应激和清除氧自由基是治疗机体产生疾病的重要策略。Nrf2-ARE信号通路是机体内极为重要的内源性防御体系,通过调控Nrf2-ARE信号通路可起到维持机体细胞内氧化还原状态平衡和降低氧化应激造成损伤的作用。综述了Nrf2-ARE信号通路调控机体抗氧化酶活性、与机体氧化应激相关疾病的相关性及其与其他信号通路的关系,以期为深入了解Nrf2-ARE信号通路在抵抗机体产生氧化应激损伤的作用和机制方面提供参考。

Oxidative stress injury is considered to be closely associated with development of a variety of diseases in the body.When oxidative stress is severe, the inhibiting of oxidative stress and scavenging of oxygen free radical can be served as an important strategy for treatment of related diseases. Nrf2-ARE signaling pathway is an extremely important endogenous defense system in the body, which can maintain the balance of redox state in the cell and reduce the injuries produced by oxidative stress by regulating Nrf2-ARE signaling pathways. The role of Nrf2-ARE pathway in regulating antioxidant enzymes activity, the association of Nrf2-ARE pathway with the emergence of oxidative stress related diseases, and the relationship of Nrf2-ARE pathway with other signaling pathways were reviewed in this article, so as to provide a reference for a better understanding of the role of Nrf2-ARE signaling pathway in resisting oxidation stress injury in the body as well as of related mechanisms.