亚胺培南/西司他丁治疗重症医院获得性肺炎临床观察

Clinical observation of imipenem/cilastatin in the treatment of severe hospital acquired pneumonia

目的探讨亚胺培南/西司他丁治疗重症医院获得性肺炎的临床效果,为临床诊治提供参考依据。方法选择2011年1月-2015年1月80例重症医院获得性肺炎患者,按照数字表法随机分为观察组与对照组,各40例;观察组使用亚胺培南/西司他丁治疗,对照组使用哌拉西林/他唑巴坦治疗,对比两组患者治疗有效率及细菌清除率,数据采用SPSS 21.0软件进行统计分析。结果观察组患者治疗有效率为85.00%,明显高于对照组的65.00%,两组比较差异有统计学意义(P<0.05);观察组细菌清除率为68.18%,对照组为60.00%,两组比较差异无统计学意义。结论亚胺培南/西司他丁治疗重症医院获得性肺炎临床效果好,优于哌拉西林/他唑巴坦。

OBJECTIVE To investigate clinical effect of imipenem/cilastatin in the treatment of severe hospital acquired pneumonia,and to provide reference for clinical treatment.METHODS From Jan.2011 to Jan.2015,80 cases of patients with severe hospital-acquired pneumonia were selected.According to the digital form,they were randomly divided into observation group and control group,with 40 cases in each group.Observation group used imipenem/cilastatin sodium for treatment and control group used tazobactam for treatment,treatment effective rate and bacterial clearance rate in both groups were compared.Data were analyzed with SPSS 21.0.RESULTS Effective rate of observation group was 85.00%,significantly higher than control group 65.00%（P〈0.05）.In observation group bacterial clearance rate was 68.18%,and 60.00%in the control group,the difference was not significant.CONCLUSIONImipenem/cilastatin has good clinical effect for treatment of severe hospital-acquired pneumonia,and is better than tazobactam.