垂体腺瘤患者术后脑脊液漏继发颅内感染的临床分析

Clinical analysis of postoperative cerebrospinal fluid leakage secondary to intracranial infection in patients with pituitary adenoma

目的分析垂体腺瘤患者术后脑脊液漏继发颅内感染相关因素,为临床手术治疗减少颅内感染提供参考依据。方法回顾性分析2011年2月-2015年2月在医院接受治疗的532例垂体腺瘤患者临床资料,分析垂体腺瘤术后脑脊液漏继发颅内感染的危险因素,数据采用SPSS 19.0软件进行统计分析。结果 532例垂体腺瘤患者术后发生颅内感染33例,感染率为6.2%;单因素分析显示,手术时间长、侵入性操作、术后脑脊液漏、术后有留置引流管、术后应用激素均是发生颅内感染的相关危险因素(P<0.05)。结论术后脑脊液漏是发生颅内感染的最大独立危险因素,可进行针对性的预防干预。

OBJECTIVE To clinically analyze postoperative cerebrospinal fluid leakage secondary to intracranial infections in patients with pituitary adenoma,and to provide scientific basis for clinical treatment of postoperative intracranial infections.METHODS A total of 532 patients with pituitary adenoma suffering from postoperative intracranial infections were selected from Feb.2011 to Feb.2015.The risk factors of postoperative cerebrospinal fluid leakage secondary to intracranial infections were explored.The results were statistically analyzed by software SPSS 19.0.RESULTS Among the 532 patients,33of them were inflicted with postoperative intracranial infections and the infection rate was 6.2%.The result of single factor analysis showed that the long-time operation,invasive procedures,postoperative cerebrospinal fluid leakage,postoperative indwelling lead pipe,postoperative hormone application were the related risk factors（P〈0.05）.CONCLUSIONPostoperative cerebrospinal fluid leakage is the biggest independent risk factor for intracranial infections.Treatment can be targeted on prevention intervention.