阑尾切除患者术后切口感染病原菌分布与耐药性研究

Clinical study on pathogen distribution and drug resistance in postoperative incision infections of patients with appendectomy surgery

目的探讨阑尾切除患者术后切口感染的病原菌分布及耐药性,为临床合理使用抗菌药物提供参考依据。方法选取医院2010年1月-2015年5月收治的400例阑尾切除术患者作为研究对象,分析阑尾切除术后切口感染的病原菌分布及耐药性,数据采用SPSS 17.0软件进行统计分析。结果 400例患者中发生切口感染22例,感染率为5.50%;共检出30株病原菌,以革兰阴性菌为主,占70.00%;大肠埃希菌对头孢唑林、头孢哌酮、头孢噻肟耐药率较高,均>40.00%;铜绿假单胞菌对头孢他啶、头孢唑林、头孢哌酮、头孢噻肟耐药率较高,均>65.00%;粪肠球菌对头孢他啶、头孢曲松、青霉素耐药率均为100.00%。结论阑尾切除术后切口感染病原菌分布以大肠埃希菌为主,感染病原菌对于头孢类、喹诺酮类抗菌药物耐药性高,切口感染发生后依据病原菌分布及药敏性合理选择抗菌药物,有效控制感染。

OBJECTIVE To study the pathogen distribution and drug resistance in postoperative incision infections of patients with appendectomy surgery,and to provide basis for clinical use of antibiotics.METHODS A total of400 cases of appendectomy patients in our hospital were selected from Jan.2010 to May 2010.The pathogen distribution and drug resistance of incision infection of patients was studied,and the results were statistically analyzed with software SPSS 17.0.RESULTS Among the 400 cases,there were 22 cases of incision infections with an infection rate of 5.50%,in which 30 strains of pathogens were detected,including 70.00% of gram-negative bacteria.Escherichia coli was strongly resistant to cefazolin,cefoperazone and cefotaxime with the resistance rate above40.00%;Pseudomonas aeruginosa was resistant to ceftazidime,cefazolin,cefoperazone and cefotaxime with the resistance rate above 65.00%;Enterococcus faecalis was resistant to ceftazidime,ceftriaxone and penicillin with the resistance rate of 100.00%.CONCLUSION Escherichia coli is the main pathogen in incision infections of patients with appendectomy surgery.Infection pathogens are strongly resistant to cephalosporins and quinolones.Appropriate antibiotics can be chosen according to pathogen distribution to effectively control and eliminate infections.