2%夫西地酸乳膏治疗细菌感染性皮肤病疗效与安全性观察

Clinical effect and safety of 2% fusidic acid cream for the treatment of bacterial skin infections

目的探讨夫西地酸乳膏治疗细菌感染性皮肤病的临床效果及安全性,为临床诊治提供参考依据。方法选择2012年1月-2015年1月90例细菌感染性皮肤病患者,按照治疗方法分为对照组与观察组,对照组40例患者使用2%莫匹罗星软膏治疗,观察组50例患者使用2%夫西地酸乳膏治疗;对比两组患者的治疗有效率及不良反应,数据采用SPSS 21.0软件进行统计分析。结果观察组与对照组治疗后相比治疗前症状EASI评分、瘙痒评分对比差异均有明显改善,对比差异有统计学意义(P<0.05);观察组治疗有效率为96.0%、对照组为92.5%,差异无统计学意义;对照组出现皮肤瘙痒及局部灼热感各1例,观察组出现1例局部灼热感,均未作特殊处理,自行缓解,两组不良反应对比差异无统计学意义。结论 2%夫西地酸乳膏治疗细菌感染性皮肤病临床效果好,利于缓解患者症状,值得临床推广应用。

OBJECTIVE To investigate clinical effect and safety of 2%fusidic acid cream for the treatment for bacterial skin infections,and to provide a reference for clinical treatment.METHODS From Jan.2012 to Jan.2015,90 patients with skin disorders caused by bacterial infections were selected,and they were divided into two groups according to treatment,that were observation group and control group.Control group（40patients）used 2% mupirocin ointment,and observation group（50patients）used 2%fusidic acid cream.Treatment efficiency rate and adverse reactions were compared between two groups.Data were analyzed with SPSS 21.0.RESULTS Both in observation group and control group,symptoms EASI scores before and after treatment,and itching scores showed significant improvement（P〈0.05）;treatment efficiency rate of observation group was 96.0%,compared to control group 92.5%,the difference was not significant.There was 1case of skin itch and 1case of local burning sensation in control group,1case of local burning sensation in observation group,and the difference was not significant.CONCLUSION2%fusidic acid cream has good clinical effect for the treatment of bacterial skin infections,which will alleviate symptoms,and is worthy of clinical application.