口腔癌放疗患者口腔感染的危险因素调查

Risk factors of oral infections in oral cancer patients receiving radiation therapy

目的探讨口腔癌患者放疗后口腔感染的危险因素,为临床预防感染提供参考依据。方法回顾性分析2013年5月-2015年6月200例接受放疗的口腔癌患者临床资料,分析口腔感染率及其感染危险因素,数据采用SPSS 19.0软件进行统计分析。结果共有36例发生口腔感染,感染率为18.00%;logistic多因素分析显示,年龄>50岁、血清白蛋白<40g/L、多次放疗、粒细胞绝对值<0.5×109/L均为导致口腔感染发生的独立危险因素(P<0.05),而预防性应用抗菌药物为口腔感染的保护因素。结论口腔感染在接受放疗治疗的口腔癌患者中有着一定的发生率,应针对口腔感染危险因素的患者给予必要的预防措施。

OBJECTIVE To investigate risk factors of oral infections after radiation therapy for oral cancer,and to provide clinical reference for oral infection prevention.METHODS Clinical data of 200 patients with oral cancer treated by radiation therapy from May 2013 to Jun.2015 were analyzed retrospectively,and the incidence rate of oral infections and risk factors were analyzed.Data were analyzed with SPSS 19.0statistically.RESULTS A total of 36 cases of oral infections occurred,and the incidence rate was 18.00%.Multiple factors and logistic analysis showed that age50,albumin 40g/l,multiple radiotherapy,the absolute value of neutropenia0.5×109/L were individual risk factors for oral infections（P〈0.05）,and the preventive use of antibiotics was protective factors for oral infections.CONCLUSION Oral infection in oral cancer patients receiving radiation has a certain incidence,clinical attention should be paid to risk factors of oral infections,and provide patients with necessary prevention and treatment.