摘要
外源性16S rRNA甲基化酶能介导细菌对多种氨基糖苷类抗菌药物高水平耐药,目前已发现10种外源性16S rRNA甲基化酶;该综述分析了外源性16S rRNA甲基化酶与两类内源性16S rRNA甲基化酶的联系,发现外源性16S rRNA甲基化酶可阻碍特定的内源性16S rRNA甲基化酶的甲基化作用,影响细菌的生长及对抗菌药物的敏感性,对基因环境的分析表明外源性16S rRNA甲基化酶基因常与其他耐药基因位于同一可移动基因元件上,耐药机制复杂,应继续监测外源性16S rRNA甲基化酶的流行情况,深入探讨其耐药机制的形成,以期早日改善临床致病菌耐药情况。
Exogenous 16S rRNA methylase can mediate a mechanism of bacteria with high level resistance to many aminoglycosides,and ten kinds of exogenous 16S rRNA methylase have already been reported.This essay has analyzed the association of exogenous 16S rRNA methylase with two kinds of endogenous 16S rRNA methylase.The result showed that exogenous 16S rRNA methylase could defect the growth of strains and change the strain＇s susceptibility to antibiotics by hindering the methylation of specific endogenous 16S rRNA methylase.The analysis of genetic environment suggested that exogenous 16S rRNA methylase produced a complex resistance mechanism as their encoding genes are mostly locating on transferable plasmids with other resistance determinants.It required us to have a further monitoring of the exogenous 16S rRNA methylase and seek for the resistance mechanism to minimize the occurrence of drug resistance.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2016年第7期1674-1676,1680,共4页
Chinese Journal of Nosocomiology
基金
浙江省自然科学基金资助项目(LY13H190008)
宁波市社发重大基金资助项目(2010C50038)
