经气管镜微创介入治疗中心型肺癌疗效分析

Clinical efficacy of chemotherapy combined with location intervened by bronchoscope in central lung cancer

目的观察化疗联合经气管镜微创介入治疗中晚期中心型肺癌的临床疗效。方法选择36例中晚期中心型肺癌患者,采用全身标准一线化疗方案吉西他滨+顺铂(GP)联合经气管镜微创介入治疗即经气管镜,氩氦刀切除肿瘤后放置气管支架(联合治疗组),两个化疗周期后评定临床疗效;同时设对照组即单纯化疗组(49例)仅采用全身标准一线化疗方案吉西他滨+顺铂(GP)方案治疗两个周期后评价疗效。结果联合治疗组有效率为72.2%,症状缓解率为69.4%,1年生存率77.8%;单纯化疗组有效率为28.6%,症状缓解率为38.8%;1年生存率44.9%,两组比较差异均有统计学意义(P<0.01)。结论化疗联合气管镜微创介入治疗中心型肺癌疗效显著、症状缓解迅速,是目前治疗中晚期中心型肺癌的较好选择。

Objective To explore the clinical effects of advanced central lung cancer by chemotherapy combined with location intervened with electronic bronchoscopy.Methods Thirty-six cases of advanced central lung cancer patients were delt with standard first GP chemotherapy combined with location intervened by the electronic bronchoscopey.Treatment involved respectively argon plasma coagulation group（APC）then placed the bronchial support into bronchia.The another central group accepted simple anti-tumor drugs standard first GP treated.Both groups were evaluated for curative effect after two treatment cycles（21days a cycle）.Results The effective rate of combined group was 72.2% and the remission rate of symptoms was 69.4%.The one-year survival rate was 77.8%.The effective rate of the simple chemotherapy group was 28.6% and the remission rate of symptoms was 38.8%.The one-year survival rate was 44.9%.There were significant differences between two groups（P〈0.01）.Conclusion The efficacy of the chemotherapy combined with location intervened by the electronic bronchoscopy was significantly better than that of simple chemotherapy.It is a better way to treat advanced central lung cancer patients currently and it rapidly relieves the clinical symptoms.