基于动脉硬化检测仪测定的动脉硬化与红细胞参数的相关性

Correlation Between Arterial Stiffness Based on the Measurement of Arterial Stiffness Detector and Red Blood Cell Parameters

目的研究体检人群动脉硬化与红细胞参数的关系。方法选择2014年7月在中国中医科学院广安门医院南区的体检者304人,询问病史、测量身高、体重、血压等,检测血常规、血生物化学等指标,应用欧姆龙BP-203 RPEⅢ动脉硬化检测仪检测体检人群的动脉弹性,根据臂踝脉搏波传导速度(ba PWV)分为动脉正常组(n=117)、轻度硬化组(n=112)和硬化组(n=75),将三组之间的红细胞参数,包括红细胞(RBC)、血红蛋白(HGB)、红细胞压积(HCT)、平均红细胞体积(MCV)、平均红细胞血红蛋白量(MCH)、平均红细胞血红蛋白浓度(MCHC)、红细胞分布宽度变异系数(RDW-CV)、红细胞分布宽度标准差(RDW-SD)进行比较分析。结果硬化组MCV、RDWCV明显高于动脉正常组(P<0.05或P<0.01);硬化组RDW-SD高于轻度硬化组(P<0.05),轻度硬化组RDWSD高于动脉正常组(P<0.05)。相关性分析显示,HGB、HCT、MCV、MCH、RDW-CV、RDW-SD与ba PWV呈正相关。应用多元线性逐步回归分析,最终纳入回归方程的指标是RDW-SD、HGB,回归方程为ba PWV=-898.411+39.657×RDW-SD+3.171×HGB。结论 RDW-SD对评价动脉硬化的程度具有一定的临床参考意义,同时HGB是动脉硬化的影响因子。

Aim To study the relationship between arterial stiffness and red blood cell parameters. Methods304 patients were chosen in the Medical Center of the Southern District of Guang＇anmen Hospital of China Academy of Chinese Medical Sciences in July 2014. The medical history,measured height,weight,blood pressure,blood routine,biochemical indicators were asked,and Omron BP-203 RPE Ⅲ arterial stiffness detector was applied to test their arterial elasticity. According to brachial-ankle pulse wave velocity（ ba PWV）,they were divided into normal group（ n = 117）,mild sclerosis group（ n = 112） and atherosclerosis group（ n = 75）,and red blood cell parameters were compared among the three groups. Results The mean corpuscular volume（ MCV） and red blood cell distribution width-correlation variance（ RDW-CV） in the atherosclerosis group were significantly higher than that in the normal group（ P〈0. 05 or P〈0. 01）. The red blood cell distribution width-standard deviation（ RDW-SD） in the atherosclerosis group was higher than that in the mild sclerosis group（ P〈0. 05）. The RDW-SD in the mild sclerosis group was higher than that in the normal group（ P〈0. 05）. Correlation analysis showed hemoglobin（ HGB）,hematocrit（ HCT）,MCV,mean corpuscular hemoglobin（ MCH）,RDW-CV,RDW-SD and ba PWV were positively correlated. Multiple linear regression analysis showed the final regression equation included indicators was RDW-SD,HGB,the regression equation was ba PWV =- 898. 411 ＋ 39. 657 × RDW-SD ＋ 3. 171 × HGB. Conclusion RDW-SD have a certain degree of clinical referenceof atherosclerosis,while HGB is the impact factor of atherosclerosis.