不同右美托咪定给药方式在妇科腹腔镜手术麻醉中的临床效果及安全性观察

Observation on the Clinical Effect and Safety of Different Administrations of Dexmedetomidine During Anesthesia in Gynecological Laparoscopic Surgery

目的探讨妇科腹腔镜手术麻醉治疗中使用右美托咪定的不同给药方式治疗的效果和安全性。方法选择2014年2月~2015年3月我院的68例妇产科腹腔镜手术患者来进行研究分析,将其分成AB两组,均有34例,均使用右美托咪定治疗,A组使用单次静注给药,B组采取静脉滴注给药,对两种给药方式的效果进行比较分析。结果 A组患者拔管时间、定向力恢复时间、PACU停留时间均要比B组优秀,A组的不良反应率是11.8%,B组不良反应率是29.4%,结果差异存在统计学意义（P〈0.05）。结论妇科腹腔镜麻醉手术治疗前使用静注右美托咪定的治疗方式能够有效避免气腹后的血流动力学波动,降低不良反应发生率,对患者的康复有较大帮助。

Objective To investigate the therapeutic effect and safety of different administrations of dexmedetomidine during anesthesia in gynecological laparoscopic surgery. Methods The analysis was based on the 68 patients who went through laparoscopic surgery at our hospital from February 2014 to March 2015. Those patients were divided into two groups, group A and B with 34 patients respectively. Patients in the group A received intravenous injection, while those in the group B took intravenous infusion. A comparison was made as to the effects of those two different treatments. Results Patients in Group A undergo shorter extubation, orientation recovery, and stay in PACU than those in group B. The adverse reaction rate of the Group A was 11.8%, compared with 29.4% of Group B. The result showed a significant difference（P0.05）. Conclusion Intravenous injection of dexmedetomidine before anesthesia in gynecological laparoscopic surgery can effectively avoid hemodynamic fluctuations after pneumoperitoneum. The injection can also reduce the chance of adverse reactions and is safer and more effective and conducive to a speedy recovery.