甘草酸二铵对稳定期慢性阻塞性肺疾病患者肺功能及炎症指标的影响

Effect of Diammonium Glycyrrhizinate on Stable Lung Function and Inflammatory Markers in Patients With Chronic Obstructive Pulmonary Disease

目的探讨甘草酸二铵(DG)对稳定期慢性阻塞性肺疾病(COPD)患者肺功能及炎症指标的影响。方法 50例稳定期COPD患者随机分为观察组和对照组,观察组在止咳治疗基础上给予DG治疗,对照组在止咳基础上给予茶碱缓释片治疗。结果与对照组相比,观察组肺功能提高,血清IL-6、IL-8、TNF-α水平下降,两组差异有统计学意义(P<0.05)。结论甘草酸二铵能减轻稳定期COPD患者的炎症反应,提高患者的肺功能。

Objective To investigate the effect of dominium glycyrrhizin ate for stable chronic obstructive pulmonary disease（COPD） and lung function in patients with inflammatory markers. Methods 50 patients with chronic obstructive pulmonary disease were randomly divided into observation group and control group. Observation group was given diammonium glycyrrhizinate on the basis of general treatment, the control group was given theophylline treatment on the basis of general treatment. Results Compared with the control group, the observation group had improved lung function, serum IL-6, IL-8, TNF-α levels decreased, the difference was statistically significant（P0.05）. Conclusion Diammonium glycyrrhizinate can reduce inflammation in patients with stable chronic obstructive pulmonary disease, and improve lung function.