醛固酮受体拮抗剂治疗糖尿病肾病的应用价值及可行性研究

Application Value and Feasibility of Aldosterone Receptor Antagonist in the Treatment of Diabetic Nephropathy

目的评探讨醛固酮受体拮抗剂治疗糖尿病肾病的可行性研究和临床应用价值。方法将来我院就诊的糖尿病肾病患者90例,随机分为观察组和对照组,每组45例,对照组在常规治疗的基础上口服厄贝沙坦300 mg,每天1次;观察组在常规治疗的基础上口服螺内酯25 mg,每天1次,两组治疗时间均为3个月。结果观察组血钾、Cr、24 h尿蛋白等临床指标均高于对照组,P<0.05,差异具有统计学意义。结论糖尿病肾病的患者通过给予醛固酮受体拮抗剂进行治疗,在临床中可获得较为良好的效果,有效缓解临床症状。

Objective To investigate the clinical value and feasibility of treating diabetic nephropathy by aldosterone receptor antagonists. Methods To select 90 cases who suffer from diabetes nephropathy,then randomly divided them into observation group and control group. Each group had 45 patients. The control group received irbesartan 300 mg orally, once per day on the basis of routine therapy. But observation group received 25 mg oral spironolactone, once a day on the basis of conventional treatment. The treatment time of the two groups was 3 months. Results The blood potassium,Cr and 24 hours urine protein and other clinical indicators of observation group of were higher than those of the control group patients（P0.05）, the difference was statistically significant. Conclusion Patients who suffer from diabetic nephropathy,obtain more obvious effects in clinical and can effectively relieve the symptoms by using the aldosterone receptor antagonists.