芍药甙的结构修饰

Structural Modification of Paeoniflorin

芍药甙是从中药白芍、赤芍等中提取出来的一种单萜苷类化合物,它有1个蒎烷骨架及1个缩醛结构,这一结构在一定的酸性条件下可水解为成醛基。经水解后,芍药甙的主要功能基团与断马钱子苷(Secologanin)较为相似(都具有单萜及醛基的结构),而Secologanin即是合成单萜吲哚类生物碱的主要前体物。可以用芍药甙作为前体物,对其进行结构修饰,主要是与吲哚类(色氨酸,5-羟基色氨酸)作用,来合成一类全新的单萜吲哚类生物碱。此项工作将为进一步研究单萜吲哚类生物碱的丰富结构提供依据,并为新药的研制与开发提供一个新的思路。

Paeoniflorin is a monoterpenoid which is isolated from Paeonia lasectiflora pall, and shown to possess the pinene skeleton unit. Moreover, it has unique structure which can be hydrolyzed into aldehyde under the certain acidic condition. The paeoniflorin can be seen as a simple monoterpenoid. The structural features common to paeoniflorin and monoterpenoid glucoside secologanin which is used as the starting matter in the synthesis of monoterpenoid indole alkaloids. Most monoterpenoid indole alkaloid contain two structural elements： tryptamine and unit derived from secologanin.Therefore, it is certain that we can employ paeoniflorin as the unit by condensation with tryptamine to synthesize the new kind of monoterpenoid indole alkaloid. This experiment will not only provide more documents for the further study up on the rich variey of functionality and skeleton of monoterpenoid indole alkaloids, but also a new idea for the exploitation of new medicine.