FDP和D-二聚体在急性脑梗塞和深静脉血栓中的诊断价值

The Diagnostic Value of FDP and D-dimer in Patient with Acute Cerebral Infarction and Deep Vein Thrombosis

目的探讨FDP和D-二聚体在急性脑梗塞和深静脉血栓中的诊断价值。方法回顾性分析急性脑梗塞患者295例、深静脉血栓患者84例和正常对照组300例的血浆FDP和D-二聚体水平,并进行统计分析。结果急性脑梗塞组和深静脉血栓组与对照组的血浆D-二聚体、FDP水平经方差分析,差异均有统计学意义存在显著差异(P<0.01),深静脉血栓组较之急性脑梗塞组水平明显升高,经统计分析差异有统计学意义存在显著差异(P<0.01),FDP和D-二聚体在对急性脑梗塞中的诊断敏感性分别为21.5%和36.2%,在对深静脉血栓中的诊断敏感性为44.1%和64.2%;二者在对急性脑梗塞中的阴性预测价值分别为48.8%和53.8%,而对在深静脉血栓中的阴性预测价值为86.1%和90.4%,ROC曲线分析表明二者在对急性脑梗塞和深静脉血栓中具有一定的诊断价值。结论血浆标志物FDP和D-二聚体可作为急性血管栓塞性疾病的辅助诊断指标,特别是在对深静脉血栓中的阴性排除价值较大。

Objective The study was to investigate the diagnostic values of FDP and D-dimer in patient with acute cerebral infarction（ACI） and deep vein thrombosis（DVT）. Methods The plasma concentrations of FDP and D-dimer were retrospectively statistically analysed, which included 295 cases of ACI, 84 cases of DVT,and 300 cases without the abovementioned diseases were set up as control. Results FDP and D-dimerin varied in ACI,DVT and the control（P〈0.01）. Patients with DVT, compared to those with ACI showed a significant increase（P〈0.01）.Diagnostic sensitivity of FDP and D-dimer was 21.5% and 36.2% in ACI, and 44.1% and 64.2% in DVT,while negative predictive value was 48.8% and 53.8% in ACI,and 86.1% and 90.4% in DVT. ROC curve analysis suggested that FDP and D-dimer had certain diagnostic value in patients with ACI and DVT. Conclusion Plasma markers of FDP and D-dimer can be used as diagnostic marker of acute vascular thromboembolic diseases, particularly in showing higher negative exclusion value in deep venous thrombosis disease.