东风-同济队列研究：研究方法及调查对象基线和第一次随访特征

Dongfeng-Tongji cohort： methodology of the survey and the characteristics of baseline and initial population of follow-up program

目的 探讨环境、职业因素、个人生活方式、遗传因素和遗传-环境交互作用对某职业人群的主要慢性病发生和发展的影响。方法 东风-同济队列研究为一项建立有生物样本库的前瞻性开放式队列研究。2008-2009年对湖北省十堰市东风汽车公司退休职工进行基线调查,包括问卷调查、体格检查、生化指标检查和血液样本采集。计划每5年随访一次。2013年4-10月完成了第一次随访,再次进行了问卷调查、体格检查、生化指标检查和血液样本采集。结果 基线调查共邀请了31000名东风汽车公司退休职工,其中27009名（占87%）退休职工同意参加并提供了流行病学调查信息和基线血液样本。东风-同济队列研究入选人群的基线平均年龄为63.6岁,其中男性占44.6%。2013年第一次随访共纳入了38295名退休职工,男性占44.7%。在2013年第一次随访研究人群中,40.5%的参与者为高中及以上学历。队列人群男性和女性的现在吸烟率分别为33.6%和2.0%,饮酒率分别为39.9%和10.6%;38295人群中流行病学调查自我报告的慢性疾病患病率分别为高血压41.1%、高脂血症24.3%、糖尿病13.9%、冠心病16.7%、中风5.1%、慢性支气管炎12.7%和哮喘4.0%;男性高血压和中风的自我报告患病率高于女性。2008年基线人群中,共有25978人随访到相关信息,2008年基线人群第一次的随访率为96.2%。结论 东风-同济队列的建立为研究遗传、环境及遗传-环境交互作用对慢性病发生和发展提供了重要资源。

Objective To explore the effects of related environment, occupational, lifestyle, genetic factors as well as their interactions on the etiology of major chronic diseases in an occupational population. Methods Dongfeng-Tongji cohort（DFTJ cohort）, one of the large prospective cohort studies with biobank. Baseline study was conducted in Shiyan city, Hubei province from 2008 to 2009. This cohort study included questionnaire, physical examination and tests on blood samples. Dongfeng-Tongji cohort was followed up every 5 years and the first follow-up program was completed, from April to October in 2013. During the first follow-up period in 2013, questionnaire, physical examination, clinical and blood sample tests were conducted again. Results 27009 retired participants with mean age of 63.6 years including 44.6% males, were recruited in this study. In the first follow-up program in 2013, among 38295 subjects（44.7% males）, 40.5% of them received diploma from high school or above. Prevalence rates of current regular smokers were 33.6% in men and 2.0% in women and the rates on current alcohol drinkers were 39.9% in men and 10.6% in women. The prevalence rates on self-reported hypertension, hypercholesterolemia, diabetes mellitus, coronary heart disease, stroke, chronic bronchitis, and asthma were 41.1%, 24.3%, 13.9%, 16.7%, 5.1%, 12.7% and 4.0%, respectively. The self-reported prevalence of hypertension and stroke in males was higher than that in females. 25978 individuals who were involved in the baseline database successfully completed the followed up program in 2013, with the follow-up rate as 96.2%. Conclusion The DFTJ cohort study offered us an opportunity to explore the effects of environmental, genetic, as well as their interactions with major chronic diseases in a Chinese occupational population.